PMID- 19505958
OWN - NLM
STAT- MEDLINE
DCOM- 20091102
LR  - 20230815
IS  - 1460-2083 (Electronic)
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 18
IP  - 17
DP  - 2009 Sep 1
TI  - Functional interaction of mammalian target of rapamycin complexes in regulating 
      mammalian cell size and cell cycle.
PG  - 3298-310
LID - 10.1093/hmg/ddp271 [doi]
AB  - Dysregulation of the mammalian target of rapamycin (mTOR) kinase pathway is 
      centrally involved in a wide variety of cancers and human genetic diseases. In 
      mammalian cells, mTOR is part of two different kinase complexes: mTORC1 composed 
      of mTOR, raptor and mLST8, and mTORC2 containing mTOR, rictor, sin1 and mLST8. 
      Whereas, mTORC1 is known to be a pivotal regulator of cell size and cell cycle 
      control, the question whether the recently discovered mTORC2 complex is involved 
      in these processes remains elusive. We report here that the mTORC1-mediated 
      consequences on cell cycle and cell size are separable and do not involve effects 
      on mTORC2 activity. However, we show that mTORC2 itself is a potent regulator of 
      mammalian cell size and cell cycle via a mechanism involving the Akt/TSC2/Rheb 
      cascade. Our data are of relevance for the understanding of the molecular 
      development of the many human diseases caused by deregulation of upstream and 
      downstream effectors of mTOR.
FAU - Rosner, Margit
AU  - Rosner M
AD  - Medical Genetics, Medical University of Vienna, 1090 Vienna, Austria.
FAU - Fuchs, Christiane
AU  - Fuchs C
FAU - Siegel, Nicol
AU  - Siegel N
FAU - Valli, Alessandro
AU  - Valli A
FAU - Hengstschlager, Markus
AU  - Hengstschlager M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090608
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Multiprotein Complexes)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - *Cell Cycle
MH  - Cell Line
MH  - *Cell Size
MH  - Humans
MH  - Multiprotein Complexes/genetics/*metabolism
MH  - Protein Kinases/genetics/*metabolism
MH  - TOR Serine-Threonine Kinases
PMC - PMC2722991
EDAT- 2009/06/10 09:00
MHDA- 2009/11/03 06:00
PMCR- 2009/06/08
CRDT- 2009/06/10 09:00
PHST- 2009/06/10 09:00 [entrez]
PHST- 2009/06/10 09:00 [pubmed]
PHST- 2009/11/03 06:00 [medline]
PHST- 2009/06/08 00:00 [pmc-release]
AID - ddp271 [pii]
AID - 10.1093/hmg/ddp271 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2009 Sep 1;18(17):3298-310. doi: 10.1093/hmg/ddp271. Epub 2009 Jun 
      8.