PMID- 19509619
OWN - NLM
STAT- MEDLINE
DCOM- 20090630
LR  - 20220330
IS  - 1529-8809 (Electronic)
IS  - 0022-5282 (Linking)
VI  - 66
IP  - 6
DP  - 2009 Jun
TI  - Serum IL-8 and MCP-1 concentration do not identify patients with enlarging 
      contusions after traumatic brain injury.
PG  - 1591-7; discussion 1598
LID - 10.1097/TA.0b013e31819a0344 [doi]
AB  - BACKGROUND: Cerebral contusions contain numerous leukocytes, and a temporal 
      relationship exists among cerebral chemokine expression, leukocyte recruitment, 
      and contusion enlargement. This would suggest a role for chemokines in contusion 
      development. However, it has not been established if serum concentrations of 
      chemokines such as interleukin-8 (IL-8) or monocyte chemoattractant protein-1 
      (MCP-1) change with contusion enlargement. METHODS: Eighteen adult patients with 
      severe contusional traumatic brain injury, on computerized tomography, were 
      identified. Patients with diffuse injuries or extradural and subdural hematomas 
      associated with mass effect were not included in the study. Daily serum samples 
      were taken for the measurement of IL-8 and MCP-1 concentrations for up to 11 days 
      postinjury. RESULTS: In the patients who died while in intensive care, IL-8 and 
      MCP-1 were significantly greater than in those patients discharged (18 [0-202] 
      vs. 0 [0-156] pg/mL and 498 [339-1,063] vs. 368 [86-11,289] pg/mL for IL-8 and 
      MCP-1, respectively). No difference was seen in serum chemokine levels in 
      patients who deteriorated with contusion enlargement compared with those that did 
      not. The IL-8 and MCP-1 concentrations did not change significantly over time 
      either in the group as a whole or in the subgroup of patients who deteriorated. 
      CONCLUSIONS: These inflammatory mediators may be predictive of a poor outcome in 
      patients with traumatic brain injury in which contusions are the predominant 
      abnormality. However, they do not distinguish those patients who will deteriorate 
      because of contusion enlargement.
FAU - Rhodes, Jonathan
AU  - Rhodes J
AD  - Department of Anaesthesia, Critical Care and Pain Medicine, Western General 
      Hospital, University of Edinburgh, Edinburgh, Scotland. j.k.j.rhodes@sms.ed.ac.uk
FAU - Sharkey, John
AU  - Sharkey J
FAU - Andrews, Peter
AU  - Andrews P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Trauma
JT  - The Journal of trauma
JID - 0376373
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Injuries/*blood/*complications/etiology
MH  - Chemokine CCL2/*blood
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Interleukin-8/*blood
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2009/06/11 09:00
MHDA- 2009/07/01 09:00
CRDT- 2009/06/11 09:00
PHST- 2009/06/11 09:00 [entrez]
PHST- 2009/06/11 09:00 [pubmed]
PHST- 2009/07/01 09:00 [medline]
AID - 00005373-200906000-00012 [pii]
AID - 10.1097/TA.0b013e31819a0344 [doi]
PST - ppublish
SO  - J Trauma. 2009 Jun;66(6):1591-7; discussion 1598. doi: 
      10.1097/TA.0b013e31819a0344.