PMID- 19513844
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20211020
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 55
IP  - 4
DP  - 2010 Apr
TI  - Increased oxidative stress, decreased total antioxidant capacity, and iron 
      overload in untreated patients with chronic hepatitis C.
PG  - 1120-7
LID - 10.1007/s10620-009-0833-1 [doi]
AB  - The aim of this study was to determine oxidative stress in patients with 
      untreated chronic hepatitis C (CHC), relating the obtained results with iron 
      status and disease activity markers. Two groups (CHC patients and controls) were 
      studied. CHC patients presented significantly higher values than the control 
      group in some parameters: ALT, AST, GGT, iron, ferritin, and transferrin 
      saturation, and also in tert-butyl hydroperoxide initiate chemiluminescence and 
      thiobarbituric acid-reactive substances (TBARS) as well as lower values in total 
      radical-trapping antioxidant parameter (TRAP). TBARS showed a significant 
      correlation with serum AST and with transferrin saturation, whereas TRAP 
      correlated inversely with serum albumin. Serum ferritin correlated with ALT and 
      GGT, whereas serum iron did so with GGT. In conclusion, lower antioxidant 
      capacity, higher levels of pro-oxidants activity, and iron overload occur in 
      untreated patients with CHC. This greater oxidative activity could play an 
      important role in pathogenesis and evolution of hepatitis C and thus further 
      investigations.
FAU - Venturini, Danielle
AU  - Venturini D
AD  - Department of Pathology, Clinical Analysis and Toxicology, University of 
      Londrina, Londrina, Parana, Brazil.
FAU - Simao, Andrea Name Colado
AU  - Simao AN
FAU - Barbosa, Decio Sabbatini
AU  - Barbosa DS
FAU - Lavado, Edson Lopes
AU  - Lavado EL
FAU - Narciso, Victor Emanuel Soares
AU  - Narciso VE
FAU - Dichi, Isaias
AU  - Dichi I
FAU - Dichi, Jane Bandeira
AU  - Dichi JB
LA  - eng
PT  - Journal Article
DEP - 20090610
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Antioxidants)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Serum Albumin)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0 (Transferrin)
RN  - 9007-73-2 (Ferritins)
RN  - 955VYL842B (tert-Butylhydroperoxide)
RN  - E1UOL152H7 (Iron)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adult
MH  - Alanine Transaminase/blood
MH  - Antioxidants/*metabolism
MH  - Aspartate Aminotransferases/blood
MH  - Female
MH  - Ferritins/blood
MH  - Free Radical Scavengers/blood
MH  - Hepatitis C, Chronic/*blood
MH  - Humans
MH  - Iron/blood
MH  - Iron Overload/*blood
MH  - Luminescence
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Serum Albumin/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Transferrin/metabolism
MH  - gamma-Glutamyltransferase/blood
MH  - tert-Butylhydroperoxide/blood
EDAT- 2009/06/11 09:00
MHDA- 2010/04/03 06:00
CRDT- 2009/06/11 09:00
PHST- 2008/10/07 00:00 [received]
PHST- 2009/04/30 00:00 [accepted]
PHST- 2009/06/11 09:00 [entrez]
PHST- 2009/06/11 09:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - 10.1007/s10620-009-0833-1 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2010 Apr;55(4):1120-7. doi: 10.1007/s10620-009-0833-1. Epub 2009 Jun 
      10.