PMID- 19514648
OWN - NLM
STAT- MEDLINE
DCOM- 20090804
LR  - 20170306
VI  - 119
IP  - 3
DP  - 2009 Mar
TI  - Atypical clinical manifestations of multiple endocrine neoplasia type 1 syndrome.
PG  - 175-9
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a hereditary tumor syndrome 
      characterized by a genetic predisposition to develop a variety of neuroendocrine 
      tumors and hormone excess syndromes. The major components of MEN1 are 
      hyperparathyroidism due to multiple parathyroid adenomas or hyperplasia, 
      duodenopancreatic neuroendocrine tumors and pituitary adenomas, most often 
      producing prolactin. Physicians' inadequate knowledge of this clinical entity and 
      sometimes its atypical presentation result in a probable significant 
      underdiagnosis of MEN1. This describes the case of a 65-year-old female in whom 
      primary hyperparathyroidism, limited to only one parathyroid gland, was preceded 
      by acromegaly that was diagnosed 23 years earlier. This case shows that MEN1 
      manifests itself even in older groups and hyperparathyroidism may not be the 
      first symptom of this syndrome. Therefore, we believe that all subjects who, 
      regardless of age, gender and initial manifestation present with whichever the 
      major symptom should be followed up regularly for the early detection of MEN1.
FAU - Krysiak, Robert
AU  - Krysiak R
AD  - Department of Internal Diseases and Clinical Pharmacology, Medical University of 
      Silesia, Katowice, Poland. r.krysiak@interia.pl
FAU - Kajdaniuk, Dariusz
AU  - Kajdaniuk D
FAU - Marek, Bogdan
AU  - Marek B
FAU - Okopien, Boguslaw
AU  - Okopien B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Poland
TA  - Pol Arch Med Wewn
JT  - Polskie Archiwum Medycyny Wewnetrznej
JID - 0401225
SB  - IM
MH  - Acromegaly/complications
MH  - Aged
MH  - Female
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/etiology/therapy
EDAT- 2009/06/12 09:00
MHDA- 2009/08/06 09:00
CRDT- 2009/06/12 09:00
PHST- 2009/06/12 09:00 [entrez]
PHST- 2009/06/12 09:00 [pubmed]
PHST- 2009/08/06 09:00 [medline]
PST - ppublish
SO  - Pol Arch Med Wewn. 2009 Mar;119(3):175-9.