PMID- 19514928
OWN - NLM
STAT- MEDLINE
DCOM- 20091008
LR  - 20091117
IS  - 1556-9535 (Electronic)
IS  - 1556-9527 (Linking)
VI  - 28
IP  - 2
DP  - 2009
TI  - The local lymph node assay compared with the human maximization test as an 
      indicator of allergic potency in humans using patch test clinic populations.
PG  - 61-4
LID - 10.1080/15569520902793627 [doi]
AB  - The human maximization test (HMT) is a method to evaluate potency in humans, 
      while the local lymph node assay (LLNA) is a test method that allows for the 
      measuring of the allergic potency of a substance in a rodent. It has been 
      proposed that an EC3 value (the value obtained by the LLNA test, ie, the 
      concentration of an allergen leading to a 3-fold increase of baseline 
      proliferation rate) would be a reliable indicator for a compound's allergic 
      potency in humans. This paper compares the correlation between the EC3 value of a 
      compound and its allergic occurrence in the general population with the 
      correlation between the HMT of the compound and its allergic occurrence in the 
      general population, to determine the relationship to potency. The correlation 
      values when outliers were removed from the sample were -0.56 and -0.71 for LLNA 
      and HMT, respectively, suggesting that there is a possible 20% error margin in 
      LLNA's ability to predict potency. The data also suggest that other factors (such 
      as exposure) could play up to a 30% role in the determination of allergic 
      occurrence in the general population. The potency assays might be made more 
      clinically relevant for predicting allergic frequencies by including a frequency 
      factor and other factors in its dermatotoxicological interpretation.
FAU - Zaghi, Danny
AU  - Zaghi D
AD  - Albert Einstein College of Medicine, NY, USA.
FAU - Maibach, Howard I
AU  - Maibach HI
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Cutan Ocul Toxicol
JT  - Cutaneous and ocular toxicology
JID - 101266892
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/*toxicity
MH  - Animals
MH  - Cell Proliferation/drug effects
MH  - Clinical Medicine
MH  - Dermatitis, Allergic Contact/diagnosis/*etiology
MH  - Humans
MH  - *Local Lymph Node Assay
MH  - Lymph Nodes/drug effects/pathology
MH  - Mice
MH  - *Patch Tests/methods
MH  - Predictive Value of Tests
MH  - Sensory Thresholds
MH  - Skin/drug effects/pathology
EDAT- 2009/06/12 09:00
MHDA- 2009/10/09 06:00
CRDT- 2009/06/12 09:00
PHST- 2009/06/12 09:00 [entrez]
PHST- 2009/06/12 09:00 [pubmed]
PHST- 2009/10/09 06:00 [medline]
AID - 10.1080/15569520902793627 [doi]
PST - ppublish
SO  - Cutan Ocul Toxicol. 2009;28(2):61-4. doi: 10.1080/15569520902793627.