PMID- 19515610
OWN - NLM
STAT- MEDLINE
DCOM- 20090930
LR  - 20090804
IS  - 1873-5967 (Electronic)
IS  - 1386-6532 (Linking)
VI  - 46
IP  - 1
DP  - 2009 Sep
TI  - Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective 
      tissue diseases.
PG  - 43-6
LID - 10.1016/j.jcv.2009.05.010 [doi]
AB  - BACKGROUND: Little is known about the involvement of human herpesviruses 6 and 7 
      (HHV-6 and HHV-7) in autoimmune connective tissue diseases (ACTD). OBJECTIVE: To 
      determine the prevalence of active infection with HHV-6 and HHV-7 in patients 
      with ACTD. STUDY DESIGN: The presence and quantity of HHV-6 DNA was determined by 
      quantitative real-time PCR in a cross-sectional study of serum, peripheral blood 
      mononuclear cells, and tissues obtained from 58 ACTD patients and 38 healthy 
      subjects (HS). Specific anti-HHV-6 antibody titer was also measured. RESULTS: 
      HHV-6 serum viremia occurred in a significantly higher proportion of ACTD 
      patients compared to HS [26/58 (44.8%) vs. 1/38 (2.6%), p=0.001] with the highest 
      reactivation frequency [7/10 (70%)] observed in patients with scleroderma. 
      Moreover, HHV-6 in serum was associated with ACTD activity (22/38 vs. 4/20, 
      p<0.05). Higher titers of HHV-6 antibodies were found in ACTD patients than in 
      HS, although HHV-6 seroprevalence among patients with ACTD and HS was similar. 
      HHV-7 viremia was not detected in any patients or HS controls. CONCLUSION: The 
      frequent reactivation of HHV-6 in scleroderma and other ACTD, especially when 
      active, suggests that HHV-6 may play a role in the pathogenesis of these 
      diseases.
FAU - Broccolo, Francesco
AU  - Broccolo F
AD  - Department of Clinical Medicine, Prevention and Biotechnology, University of 
      Milano-Bicocca, Via Cadore, 48, 20052 Monza, Italy. francesco.broccolo@unimib.it
FAU - Drago, Francesco
AU  - Drago F
FAU - Paolino, Stefania
AU  - Paolino S
FAU - Cassina, Giulia
AU  - Cassina G
FAU - Gatto, Francesca
AU  - Gatto F
FAU - Fusetti, Lisa
AU  - Fusetti L
FAU - Matteoli, Barbara
AU  - Matteoli B
FAU - Zaccaria, Elisa
AU  - Zaccaria E
FAU - Parodi, Aurora
AU  - Parodi A
FAU - Lusso, Paolo
AU  - Lusso P
FAU - Ceccherini-Nelli, Luca
AU  - Ceccherini-Nelli L
FAU - Malnati, Mauro S
AU  - Malnati MS
LA  - eng
PT  - Journal Article
DEP - 20090609
PL  - Netherlands
TA  - J Clin Virol
JT  - Journal of clinical virology : the official publication of the Pan American 
      Society for Clinical Virology
JID - 9815671
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Viral/blood
MH  - Autoimmune Diseases/*virology
MH  - Child
MH  - Connective Tissue Diseases/*complications/*virology
MH  - Cross-Sectional Studies
MH  - DNA, Viral/genetics
MH  - Female
MH  - Herpesvirus 6, Human/isolation & purification/*physiology
MH  - Herpesvirus 7, Human/isolation & purification/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction/methods
MH  - Prevalence
MH  - Roseolovirus Infections/*complications/*epidemiology/virology
MH  - Viremia
MH  - *Virus Activation
MH  - Young Adult
EDAT- 2009/06/12 09:00
MHDA- 2009/10/01 06:00
CRDT- 2009/06/12 09:00
PHST- 2009/06/12 09:00 [entrez]
PHST- 2009/06/12 09:00 [pubmed]
PHST- 2009/10/01 06:00 [medline]
AID - S1386-6532(09)00191-7 [pii]
AID - 10.1016/j.jcv.2009.05.010 [doi]
PST - ppublish
SO  - J Clin Virol. 2009 Sep;46(1):43-6. doi: 10.1016/j.jcv.2009.05.010. Epub 2009 Jun 
      9.