PMID- 19515726 OWN - NLM STAT- MEDLINE DCOM- 20090923 LR - 20211028 IS - 1528-0020 (Electronic) IS - 0006-4971 (Linking) VI - 114 IP - 7 DP - 2009 Aug 13 TI - Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation. PG - 1437-44 LID - 10.1182/blood-2009-01-200378 [doi] AB - The importance of donor-recipient human leukocyte antigen (HLA)-DPB1 matching for the clinical outcome of unrelated hematopoietic stem cell transplantation (HSCT) is controversial. We have previously described an algorithm for nonpermissive HLA-DPB1 disparities involving HLA-DPB1*0901,*1001,*1701,*0301,*1401,*4501, based on T-cell alloreactivity patterns. By revisiting the immunogenicity of HLA-DPB1*02, a modified algorithm was developed and retrospectively tested in 621 unrelated HSCTs facilitated through the Italian Registry for oncohematologic adult patients. The modified algorithm proved to be markedly more predictive of outcome than the original one, with significantly higher Kaplan-Meier probabilities of 2-year survival in permissive compared with nonpermissive transplantations (55% vs 39%, P = .005). This was the result of increased adjusted hazards of nonrelapse mortality (hazard ratio [HR] = 1.74; confidence interval [CI], 1.19-2.53; P = .004) but not of relapse (HR = 1.02; CI, 0.73-1.42; P = .92). The increase in the hazards of overall mortality by nonpermissive HLA-DPB1 disparity was similar in 10 of 10 (HR = 2.12; CI, 1.23-3.64; P = .006) and 9 of 10 allele-matched transplantations (HR = 2.21; CI, 1.28-3.80; P = .004), both in early-stage and in advanced-stage disease. These data call for revisiting current HLA matching strategies for unrelated HSCT, suggesting that searches should be directed up-front toward identification of HLA-DPB1 permissive, 10 of 10 or 9 of 10 matched donors. FAU - Crocchiolo, Roberto AU - Crocchiolo R AD - Hematology and Bone Marrow Transplantation Unit, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy. FAU - Zino, Elisabetta AU - Zino E FAU - Vago, Luca AU - Vago L FAU - Oneto, Rosi AU - Oneto R FAU - Bruno, Barbara AU - Bruno B FAU - Pollichieni, Simona AU - Pollichieni S FAU - Sacchi, Nicoletta AU - Sacchi N FAU - Sormani, Maria Pia AU - Sormani MP FAU - Marcon, Jessica AU - Marcon J FAU - Lamparelli, Teresa AU - Lamparelli T FAU - Fanin, Renato AU - Fanin R FAU - Garbarino, Lucia AU - Garbarino L FAU - Miotti, Valeria AU - Miotti V FAU - Bandini, Giuseppe AU - Bandini G FAU - Bosi, Alberto AU - Bosi A FAU - Ciceri, Fabio AU - Ciceri F FAU - Bacigalupo, Andrea AU - Bacigalupo A FAU - Fleischhauer, Katharina AU - Fleischhauer K CN - Gruppo Italiano Trapianto di Midollo Osseo, Cellule Staminale Ematopoietiche (CSE) e Terapia Cellulare CN - Italian Bone Marrow Donor Registry LA - eng GR - GGP08201/TI_/Telethon/Italy PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20090610 PL - United States TA - Blood JT - Blood JID - 7603509 RN - 0 (HLA-DR Antigens) RN - 0 (HLA-DRB1 Chains) SB - IM CIN - Blood. 2011 May 26;117(21):5779-81. PMID: 21617014 MH - Adult MH - *Algorithms MH - Disease-Free Survival MH - Donor Selection/*methods MH - Female MH - *HLA-DR Antigens MH - HLA-DRB1 Chains MH - Hematologic Neoplasms/*mortality/*therapy MH - *Hematopoietic Stem Cell Transplantation MH - Humans MH - Italy MH - Male MH - Middle Aged MH - Recurrence MH - Registries MH - Retrospective Studies MH - Risk Factors MH - Survival Rate MH - *Tissue Donors MH - Transplantation, Homologous FIR - Scalari, P IR - Scalari P FIR - Bontempelli, M IR - Bontempelli M FIR - Prinoth, O IR - Prinoth O FIR - Carcassi, C IR - Carcassi C FIR - Marceno, R IR - Marceno R FIR - Porfirio IR - Porfirio FIR - Rombola, G IR - Rombola G FIR - Garbarino, L IR - Garbarino L FIR - Lombardo IR - Lombardo FIR - Ferrioli, G IR - Ferrioli G FIR - Poli, F IR - Poli F FIR - Scalamogna, M IR - Scalamogna M FIR - Fleischhauer, K IR - Fleischhauer K FIR - Mazzi, B IR - Mazzi B FIR - Rossi, F IR - Rossi F FIR - Mascaretti, L IR - Mascaretti L FIR - Albergoni IR - Albergoni FIR - Salvaneschi, L IR - Salvaneschi L FIR - Martinetti, M IR - Martinetti M FIR - Valentini IR - Valentini FIR - Nesci, S IR - Nesci S FIR - Papola, F IR - Papola F FIR - Scatena IR - Scatena FIR - Mariotti IR - Mariotti FIR - Perrone IR - Perrone FIR - Laurenti IR - Laurenti FIR - Grammatico, P IR - Grammatico P FIR - Mariani, M IR - Mariani M FIR - Favoino, B IR - Favoino B FIR - Miotti, V IR - Miotti V FIR - Guizzardi IR - Guizzardi FIR - Pontiero IR - Pontiero FIR - Leoni, P IR - Leoni P FIR - Rambaldi, A IR - Rambaldi A FIR - Casini, M IR - Casini M FIR - Angelucci, E IR - Angelucci E FIR - Baronciani, D IR - Baronciani D FIR - La Nasa, G IR - La Nasa G FIR - Milone, G IR - Milone G FIR - Guidi, S IR - Guidi S FIR - Bosi, A IR - Bosi A FIR - Bacigalupo, A IR - Bacigalupo A FIR - Van Lint, M T IR - Van Lint MT FIR - Dini, G IR - Dini G FIR - Corradini, P IR - Corradini P FIR - Milani, R IR - Milani R FIR - Morra, E IR - Morra E FIR - Marenco, P IR - Marenco P FIR - Lambretenghi Deliliers, G IR - Lambretenghi Deliliers G FIR - Onida, F IR - Onida F FIR - Ciceri, F IR - Ciceri F FIR - Marcatti, M IR - Marcatti M FIR - Castagna, L IR - Castagna L FIR - Pioltelli, P IR - Pioltelli P FIR - Selleri, C IR - Selleri C FIR - Zanesco, L IR - Zanesco L FIR - Scime, R IR - Scime R FIR - Musso, M IR - Musso M FIR - Alessandrino, E P IR - Alessandrino EP FIR - Locatelli, F IR - Locatelli F FIR - Visani, G IR - Visani G FIR - Di Bartolomeo, P IR - Di Bartolomeo P FIR - Papineschi, F IR - Papineschi F FIR - Favre, C IR - Favre C FIR - Iori, A P IR - Iori AP FIR - Foa, R IR - Foa R FIR - Locasciulli, A IR - Locasciulli A FIR - Majolino, I IR - Majolino I FIR - Majolino, P IR - Majolino P FIR - Leone, G IR - Leone G FIR - Arcese, W IR - Arcese W FIR - Cerretti, R IR - Cerretti R FIR - Carella, A M IR - Carella AM FIR - Cascavilla, N IR - Cascavilla N FIR - Lauria, F IR - Lauria F FIR - Mazza, P IR - Mazza P FIR - Fanin, R IR - Fanin R FIR - Cerno, M IR - Cerno M FIR - Benedetti, F IR - Benedetti F EDAT- 2009/06/12 09:00 MHDA- 2009/09/24 06:00 CRDT- 2009/06/12 09:00 PHST- 2009/06/12 09:00 [entrez] PHST- 2009/06/12 09:00 [pubmed] PHST- 2009/09/24 06:00 [medline] AID - S0006-4971(20)37437-1 [pii] AID - 10.1182/blood-2009-01-200378 [doi] PST - ppublish SO - Blood. 2009 Aug 13;114(7):1437-44. doi: 10.1182/blood-2009-01-200378. Epub 2009 Jun 10.