PMID- 19519805
OWN - NLM
STAT- MEDLINE
DCOM- 20091216
LR  - 20091120
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 120
IP  - 6
DP  - 2009 Dec
TI  - Association between human herpesvirus 6 and occurrence of multiple sclerosis 
      among Jordanian patients.
PG  - 430-5
LID - 10.1111/j.1600-0404.2009.01187.x [doi]
AB  - OBJECTIVES: Multiple sclerosis (MS) is hypothesized to be caused by an infectious 
      agent that initiates an autoimmune reaction. Among the infectious agents linked 
      to MS is human herpesvirus 6 (HHV-6). Due to the high occurrence of MS among 
      Jordanian population and the deficiency of MS studies in Jordan, the prevalence 
      of HHV-6 in sera and cerebrospinal fluids (CSFs) of 36 MS patients was 
      investigated. MATERIALS AND METHODS: To increase the sensitivity of detection, 
      nested polymerase chain reaction was utilized. RESULTS: Although we were able to 
      detect HHV-6 DNA in serum samples of 26% MS patients, no significant difference 
      was found when compared to control individuals. In addition, lack of association 
      between MS and presence of viral DNA in CSF samples was observed. Even within the 
      analyzed MS patient population, an association of HHV-6 and MS in terms of 
      gender, type of diagnosis, symptoms and disease score was not identified among 
      Jordanian patients. CONCLUSIONS: Although these results indicate lack of apparent 
      association between HHV-6 to MS among Jordanian patients, heterogeneity related 
      to genetic polymorphism as well as geographical distribution of the disease and 
      of pathogens may be of significance.
FAU - Ahram, M
AU  - Ahram M
AD  - Department of Pharmacology and Physiology, Faculty of Medicine, Mu'tah 
      University, PO Box 7, Mu'tah, Karak 61710, Jordan. dr.ahram@gmail.com
FAU - El-Omar, A
AU  - El-Omar A
FAU - Baho, Y
AU  - Baho Y
FAU - Lubad, M A
AU  - Lubad MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090610
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - DNA, Viral/blood/cerebrospinal fluid/*immunology
MH  - Female
MH  - Herpesvirus 6, Human/genetics/*immunology
MH  - Humans
MH  - Jordan
MH  - Male
MH  - Multiple Sclerosis/blood/cerebrospinal fluid/*virology
MH  - Polymerase Chain Reaction
EDAT- 2009/06/13 09:00
MHDA- 2009/12/17 06:00
CRDT- 2009/06/13 09:00
PHST- 2009/06/13 09:00 [entrez]
PHST- 2009/06/13 09:00 [pubmed]
PHST- 2009/12/17 06:00 [medline]
AID - ANE1187 [pii]
AID - 10.1111/j.1600-0404.2009.01187.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2009 Dec;120(6):430-5. doi: 10.1111/j.1600-0404.2009.01187.x. 
      Epub 2009 Jun 10.