PMID- 19522715
OWN - NLM
STAT- MEDLINE
DCOM- 20100111
LR  - 20091014
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Linking)
VI  - 23
IP  - 11
DP  - 2009 Nov
TI  - Brain-derived neurotrophic factor gene polymorphisms and serum levels in Chinese 
      atopic dermatitis patients.
PG  - 1277-81
LID - 10.1111/j.1468-3083.2009.03308.x [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays an important role in 
      the pathogenesis of atopic dermatitis (AD). Whether BDNF gene polymorphisms are 
      associated with Chinese AD remains totally unknown. OBJECTIVE: The aim is to 
      determine if BDNF gene C270T and G196A polymorphisms are associated with Chinese 
      AD, and analyse the clinical relevance of BDNF gene polymorphisms and BDNF serum 
      levels. Methods We conducted a case-control association analysis (160 patients 
      and 169 controls) in Northern Chinese subjects. Genotyping was performed by 
      restriction fragment length polymorphism, and serum levels of BDNF were measured 
      using enzyme-linked immunosorbent assay. RESULTS: For C270T, there were 
      significant differences in C/T genotype distribution (P = 0.003) and T allele 
      frequencies (P = 0.004) between AD patients and controls in the whole dataset. 
      Higher C/T genotype frequencies were found in male AD (10.6% vs. 1.1%, P = 0.018) 
      and in intrinsic AD (IAD; 15.79% vs. 2.91%, P = 0.008). No association between 
      G196A polymorphism and AD was observed in the whole cohort, while A allele was 
      much more frequent in AD patients with atopy in first-degree relatives (65.8% vs. 
      34.2%, P = 0.038). Serum BDNF levels were correlated with IAD severity as 
      measured by Scoring Atopic Dermatitis index (r = 0.576, P < 0.001). CONCLUSION: T 
      allele in C270T may be a risk factor for AD, especially in IAD and male AD. A 
      allele in G196A may be a risk factor in AD patients with atopy in first-degree 
      relatives. Serum BDNF levels were correlated with the severity of IAD.
FAU - Ma, L
AU  - Ma L
AD  - State Key Department of Dermatology, No.1 Hospital of China Medical University, 
      Shenyang, China.
FAU - Gao, X-H
AU  - Gao XH
FAU - Zhao, L-P
AU  - Zhao LP
FAU - Di, Z-H
AU  - Di ZH
FAU - Mchepange, U O
AU  - Mchepange UO
FAU - Zhang, L
AU  - Zhang L
FAU - Chen, H-D
AU  - Chen HD
FAU - Wei, H-C
AU  - Wei HC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090601
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA Primers)
SB  - IM
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor/blood/*genetics
MH  - Case-Control Studies
MH  - China
MH  - DNA Primers
MH  - Dermatitis, Atopic/ethnology/*genetics
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - *Polymorphism, Genetic
EDAT- 2009/06/16 09:00
MHDA- 2010/01/12 06:00
CRDT- 2009/06/16 09:00
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2010/01/12 06:00 [medline]
AID - JDV3308 [pii]
AID - 10.1111/j.1468-3083.2009.03308.x [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2009 Nov;23(11):1277-81. doi: 
      10.1111/j.1468-3083.2009.03308.x. Epub 2009 Jun 1.