PMID- 1952272 OWN - NLM STAT- MEDLINE DCOM- 19911127 LR - 20170214 IS - 0003-3197 (Print) IS - 0003-3197 (Linking) VI - 42 IP - 10 DP - 1991 Oct TI - Studies on blood rheology in patients with primary pulmonary hypertension. PG - 836-42 AB - The rheologic properties of blood were studied in 6 patients with primary pulmonary hypertension (PPH) and compared with those of a control group of 10 healthy subjects. Blood viscosity was studied with a rotational viscometer and blood cell deformability with a filtrometer giving values for clogging particles (CP) and red cell transit time (RCTT). Blood viscosity at varying shear rates was found to be increased both at natural (p less than 0.025-0.005) and standardized hematocrit, 45% (p less than 0.05 at 40 s-1) in patients with PPH. Red cell deformability was reduced as indicated by a significant increase of RCTT (p less than 0.01). Increased values for hematocrit (p less than 0.001), hemoglobin concentration (p less than 0.001), and erythrocyte count (p less than 0.005) were found and decreased values for mean corpuscular hemoglobin concentration (MCHC) (p less than 0.025) and HDL cholesterol (p less than 0.005). Plasma viscosity, white cell deformability, white cell count, mean corpuscular volume (MCV), and plasma fibrinogen concentration did not significantly differ from the values found in the control group. It is concluded that patients with PPH have impaired blood rheology. The hemorheologic abnormalities in these patients may be of hemodynamic significance. FAU - Persson, S U AU - Persson SU AD - Department of Internal Medicine, University Hospital, Lund, Sweden. FAU - Gustavsson, C G AU - Gustavsson CG FAU - Larsson, H AU - Larsson H FAU - Persson, S AU - Persson S LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Angiology JT - Angiology JID - 0203706 RN - 0 (Lipids) RN - 9001-32-5 (Fibrinogen) SB - IM MH - Adult MH - Blood Viscosity/*physiology MH - Cardiac Catheterization MH - Echocardiography MH - Erythrocyte Deformability/*physiology MH - Female MH - Fibrinogen/analysis MH - Hematocrit MH - Humans MH - Hypertension, Pulmonary/*blood/diagnostic imaging MH - Leukocytes/physiology MH - Lipids/blood MH - Male MH - Rheology EDAT- 1991/10/01 00:00 MHDA- 1991/10/01 00:01 CRDT- 1991/10/01 00:00 PHST- 1991/10/01 00:00 [pubmed] PHST- 1991/10/01 00:01 [medline] PHST- 1991/10/01 00:00 [entrez] AID - 10.1177/000331979104201009 [doi] PST - ppublish SO - Angiology. 1991 Oct;42(10):836-42. doi: 10.1177/000331979104201009.