PMID- 19522822
OWN - NLM
STAT- MEDLINE
DCOM- 20090713
LR  - 20090615
IS  - 1365-2796 (Electronic)
IS  - 0954-6820 (Linking)
VI  - 266
IP  - 1
DP  - 2009 Jul
TI  - Familial pituitary adenomas.
PG  - 5-18
LID - 10.1111/j.1365-2796.2009.02109.x [doi]
AB  - The majority of pituitary adenomas occur sporadically, however, about 5% of all 
      cases occur in a familial setting, of which over half are due to multiple 
      endocrine neoplasia type 1 (MEN-1) and Carney's complex (CNC). Since the late 
      1990s we have described non-MEN1/CNC familial pituitary tumours that include all 
      tumour phenotypes, a condition named familial isolated pituitary adenomas (FIPA). 
      The clinical characteristics of FIPA vary from those of sporadic pituitary 
      adenomas, as patients with FIPA have a younger age at diagnosis and larger 
      tumours. About 15% of FIPA patients have mutations in the aryl hydrocarbon 
      receptor interacting protein gene (AIP), which indicates that FIPA may have a 
      diverse genetic pathophysiology. This review describes the clinical features of 
      familial pituitary adenomas like MEN1, the MEN 1-like syndrome MEN-4, CNC, FIPA, 
      the tumour pathologies found in this setting and the genetic/molecular data that 
      have been recently reported.
FAU - Tichomirowa, M A
AU  - Tichomirowa MA
AD  - Department of Endocrinology, Centre Hospitalier Universitaire de Liege, 
      University of Liege, Domaine Universitaire du Sart-Tilman, Liege 4000, Belgium.
FAU - Daly, A F
AU  - Daly AF
FAU - Beckers, A
AU  - Beckers A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
MH  - Cell Transformation, Neoplastic/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/genetics
MH  - Mutation
MH  - Neoplastic Syndromes, Hereditary/*genetics
MH  - Pituitary Neoplasms/*genetics
RF  - 147
EDAT- 2009/06/16 09:00
MHDA- 2009/07/14 09:00
CRDT- 2009/06/16 09:00
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/07/14 09:00 [medline]
AID - JIM2109 [pii]
AID - 10.1111/j.1365-2796.2009.02109.x [doi]
PST - ppublish
SO  - J Intern Med. 2009 Jul;266(1):5-18. doi: 10.1111/j.1365-2796.2009.02109.x.