PMID- 19522825
OWN - NLM
STAT- MEDLINE
DCOM- 20090713
LR  - 20090615
IS  - 1365-2796 (Electronic)
IS  - 0954-6820 (Linking)
VI  - 266
IP  - 1
DP  - 2009 Jul
TI  - Multiple endocrine neoplasia type 1: a chromatin writer's block.
PG  - 53-9
LID - 10.1111/j.1365-2796.2009.02115.x [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is caused by inactivating germ line 
      mutations of the MEN1 tumour suppressor gene. The MEN1 gene product, menin, 
      participates in many cellular processes, including regulation of gene 
      transcription. As part of a protein complex that writes a trimethyl mark on 
      lysine 4 of histone H3 (H3K4me3), menin is involved in activating gene 
      transcription. Several functions of the menin histone methyltransferase complex 
      have been discovered through protein interaction studies. Menin can interact with 
      nuclear receptors and regulate transcription of hormone responsive target genes. 
      Menin regulates transcription of cyclin-dependent kinase inhibitor and Hox genes 
      via the chromatin-associated factor LEDGF. Aberrant expression of menin target 
      genes in tumours in MEN1 patients suggests that loss of writing of the H3K4me3 
      mark contributes to MEN1 tumourigenesis. At present, drugs are being developed 
      that target chromatin modifications. The identification of compounds that could 
      restore H3K4me3 on menin target genes would provide new therapeutic strategies 
      for MEN1 patients.
FAU - Dreijerink, K M A
AU  - Dreijerink KM
AD  - Department of Physiological Chemistry, University Medical Center Utrecht, Utrecht 
      3508 AB, The Netherlands.
FAU - Lips, C J M
AU  - Lips CJ
FAU - Timmers, H Th M
AU  - Timmers HT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
RN  - 0 (Chromatin)
RN  - 0 (Histones)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Cell Transformation, Neoplastic/genetics
MH  - Chromatin/*metabolism
MH  - Histones/metabolism
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*genetics/metabolism
MH  - Mutation
MH  - Proto-Oncogene Proteins/*genetics
RF  - 47
EDAT- 2009/06/16 09:00
MHDA- 2009/07/14 09:00
CRDT- 2009/06/16 09:00
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/07/14 09:00 [medline]
AID - JIM2115 [pii]
AID - 10.1111/j.1365-2796.2009.02115.x [doi]
PST - ppublish
SO  - J Intern Med. 2009 Jul;266(1):53-9. doi: 10.1111/j.1365-2796.2009.02115.x.