PMID- 19523541
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20131121
IS  - 1878-7568 (Electronic)
IS  - 1742-7061 (Linking)
VI  - 6
IP  - 1
DP  - 2010 Jan
TI  - Effect of silica gel on the cohesion, properties and biological performance of 
      brushite cement.
PG  - 257-65
LID - 10.1016/j.actbio.2009.06.010 [doi]
AB  - The cohesion of calcium phosphate cements can be improved by the addition of 
      substances to either the solid or liquid phase during the setting reaction. This 
      study reports the effect of silica gel on brushite cement cohesion. The cement 
      was prepared using a mixture of beta-tricalcium phosphate (beta-TCP) and 
      monocalcium phosphate monohydrate as the solid phase, while the liquid phase 
      comprised carboxylic acids silica gel. This cement presents a shorter final 
      setting time (FST), better cohesion and higher amount of unreacted beta-TCP than 
      the cement prepared without silica gel. Furthermore, in vivo experiments using 
      rabbits as an animal model showed that after 8 weeks of implantation cements 
      modified with silica gel showed a similar new bone formation volume and more 
      remaining graft in comparison with unmodified cements. Thus, the silica gel could 
      be efficiently applied to reduce cement disintegration and to decrease the 
      resorption rate of brushite cements.
FAU - Alkhraisat, Mohammad Hamdan
AU  - Alkhraisat MH
AD  - Departamento de Quimica-Fisica II, Facultad de Farmacia, UCM, Plaza: Ramon y 
      Cajal, sn, 28040 Madrid, Spain. mkhresat@farm.ucm.es
FAU - Rueda, Carmen
AU  - Rueda C
FAU - Jerez, Luis Blanco
AU  - Jerez LB
FAU - Tamimi Marino, Faleh
AU  - Tamimi Marino F
FAU - Torres, Jesus
AU  - Torres J
FAU - Gbureck, Uwe
AU  - Gbureck U
FAU - Lopez Cabarcos, Enrique
AU  - Lopez Cabarcos E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090610
PL  - England
TA  - Acta Biomater
JT  - Acta biomaterialia
JID - 101233144
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Cements)
RN  - 0 (Calcium Phosphates)
RN  - 0 (Carboxylic Acids)
RN  - 0 (Gels)
RN  - 0 (beta-tricalcium phosphate)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - O7TSZ97GEP (calcium phosphate, dibasic, dihydrate)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemistry
MH  - Bone Cements/*chemistry
MH  - Bone Regeneration
MH  - Calcium Phosphates/*chemistry
MH  - Carboxylic Acids/chemistry
MH  - Female
MH  - Gels/*chemistry
MH  - Inflammation
MH  - Macrophages/metabolism
MH  - Materials Testing
MH  - Rabbits
MH  - Silicon Dioxide/*chemistry
MH  - Time Factors
EDAT- 2009/06/16 09:00
MHDA- 2010/02/23 06:00
CRDT- 2009/06/16 09:00
PHST- 2009/03/02 00:00 [received]
PHST- 2009/06/04 00:00 [revised]
PHST- 2009/06/04 00:00 [accepted]
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - S1742-7061(09)00262-1 [pii]
AID - 10.1016/j.actbio.2009.06.010 [doi]
PST - ppublish
SO  - Acta Biomater. 2010 Jan;6(1):257-65. doi: 10.1016/j.actbio.2009.06.010. Epub 2009 
      Jun 10.