PMID- 19523767
OWN - NLM
STAT- MEDLINE
DCOM- 20091117
LR  - 20090831
IS  - 1872-6623 (Electronic)
IS  - 0304-3959 (Linking)
VI  - 145
IP  - 1-2
DP  - 2009 Sep
TI  - HLA-B62 and HLA-DQ8 are associated with Complex Regional Pain Syndrome with fixed 
      dystonia.
PG  - 82-5
LID - 10.1016/j.pain.2009.05.015 [doi]
AB  - Complex Regional Pain Syndrome (CRPS) is clinically characterized by pain in 
      combination with sensory, autonomic, and motor symptoms that may include 
      weakness, tremor, myoclonus and dystonia of the affected limb(s). The syndrome is 
      multifactorial in origin and mostly attributed to tissue injury. There is some 
      evidence that the human leukocyte antigen (HLA) system plays a role in the 
      pathophysiology of CRPS, but previous studies lacked power. Here we performed the 
      most extensive study investigating the contribution of HLA alleles (i.e. HLA-A, 
      HLA-B, HLA-DRB1, and HLA-DQB1) in 150 CRPS patients who also had fixed dystonia. 
      HLA-B62 (OR=2.05 [95% CI 1.41-2.99], P=0.0005) and HLA-DQ8 (OR=1.75 [95% CI 
      1.20-2.57], P=0.005) were found significantly associated with CRPS and dystonia. 
      The association remained significant after correction (HLA-B62 P(corrected) 
      [P(c)] = 0.02 and HLA-DQ8 P(c)=0.04). The involvement of HLA-B62 and HLA-DQ8 in 
      CRPS with dystonia may indicate that these HLA loci are implicated in the 
      susceptibility or expression of the disease.
FAU - de Rooij, Annetje M
AU  - de Rooij AM
AD  - Department of Neurology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Florencia Gosso, M
AU  - Florencia Gosso M
FAU - Haasnoot, Geert W
AU  - Haasnoot GW
FAU - Marinus, Johan
AU  - Marinus J
FAU - Verduijn, Willem
AU  - Verduijn W
FAU - Claas, Frans H J
AU  - Claas FH
FAU - van den Maagdenberg, Arn M J M
AU  - van den Maagdenberg AM
FAU - van Hilten, Jacobus J
AU  - van Hilten JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090611
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ8 antigen)
SB  - IM
MH  - Adult
MH  - Complex Regional Pain Syndromes/complications/*genetics
MH  - Dystonia/complications/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-B Antigens/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2009/06/16 09:00
MHDA- 2009/11/18 06:00
CRDT- 2009/06/16 09:00
PHST- 2009/02/20 00:00 [received]
PHST- 2009/04/21 00:00 [revised]
PHST- 2009/05/18 00:00 [accepted]
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/11/18 06:00 [medline]
AID - S0304-3959(09)00301-7 [pii]
AID - 10.1016/j.pain.2009.05.015 [doi]
PST - ppublish
SO  - Pain. 2009 Sep;145(1-2):82-5. doi: 10.1016/j.pain.2009.05.015. Epub 2009 Jun 11.