PMID- 19523780 OWN - NLM STAT- MEDLINE DCOM- 20110111 LR - 20151119 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 74 IP - 3 DP - 2010 Jun TI - Comparison of different quantification methods of late gadolinium enhancement in patients with hypertrophic cardiomyopathy. PG - e149-53 LID - 10.1016/j.ejrad.2009.05.035 [doi] AB - AIM: There is no consensus regarding the technique of quantification of late gadolinium enhancement (LGE). The aim of the study was to compare different methods of LGE quantification in patients with hypertrophic cardiomyopathy (HCM). METHODS: Cardiac magnetic resonance was performed in 33 patients with HCM. First, LGE was quantified by visual assessment by the team of experienced readers and compared with different thresholding techniques: from 1SD to 6SD above mean signal intensity (SI) of remote myocardium, above 50% of maximal SI of the enhanced area (full-width at half maximum, FWHM) and above peak SI of remote myocardium. RESULTS: LGE was present in 25 (78%) of patients. The median mass of LGE varied greatly depending on the quantification method used and was highest with the utilization of 1SD threshold [75.5 g, interquartile range (IQR): 63.3-112.3g] and lowest for FWHM method (8.4 g, IQR: 4.3-13.3g). There was no difference in mass of LGE as assessed with 6SD threshold and FWHM when compared to visual assessment (p=0.19 and p=0.1, respectively); all other thresholding techniques provided significant differences in the median LGE size when compared to visual analysis. Results for all thresholds, except FWHM were significantly correlated with visual assessment with the strongest correlation for 6SD (rho=0.956, p<0.0001). CONCLUSIONS: LGE quantification with the use of a threshold of 6SD above the mean SI of the remote myocardium provided the best agreement with visual assessment in patients with HCM. CI - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved. FAU - Spiewak, Mateusz AU - Spiewak M AD - First Department of Coronary Artery Disease, Magnetic Resonance Unit, Institute of Cardiology, ul. Alpejska 42, 04-628 Warsaw, Poland. mspiewak@ikard.pl FAU - Malek, Lukasz A AU - Malek LA FAU - Misko, Jolanta AU - Misko J FAU - Chojnowska, Lidia AU - Chojnowska L FAU - Milosz, Barbara AU - Milosz B FAU - Klopotowski, Mariusz AU - Klopotowski M FAU - Petryka, Joanna AU - Petryka J FAU - Dabrowski, Maciej AU - Dabrowski M FAU - Kepka, Cezary AU - Kepka C FAU - Ruzyllo, Witold AU - Ruzyllo W LA - eng PT - Comparative Study PT - Journal Article DEP - 20090611 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) SB - IM MH - Adolescent MH - Adult MH - Aged MH - *Algorithms MH - Cardiomyopathy, Hypertrophic/*diagnosis MH - Contrast Media/administration & dosage MH - Female MH - Humans MH - Image Enhancement/methods MH - Image Interpretation, Computer-Assisted/*methods MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - *Organometallic Compounds/administration & dosage MH - Reproducibility of Results MH - Sensitivity and Specificity MH - Young Adult EDAT- 2009/06/16 09:00 MHDA- 2011/01/12 06:00 CRDT- 2009/06/16 09:00 PHST- 2009/04/26 00:00 [received] PHST- 2009/05/19 00:00 [revised] PHST- 2009/05/20 00:00 [accepted] PHST- 2009/06/16 09:00 [entrez] PHST- 2009/06/16 09:00 [pubmed] PHST- 2011/01/12 06:00 [medline] AID - S0720-048X(09)00315-5 [pii] AID - 10.1016/j.ejrad.2009.05.035 [doi] PST - ppublish SO - Eur J Radiol. 2010 Jun;74(3):e149-53. doi: 10.1016/j.ejrad.2009.05.035. Epub 2009 Jun 11.