PMID- 19524107
OWN - NLM
STAT- MEDLINE
DCOM- 20090902
LR  - 20220309
IS  - 1872-9754 (Electronic)
IS  - 0197-0186 (Linking)
VI  - 55
IP  - 4
DP  - 2009 Sep
TI  - Local salsolinol modulates dopamine extracellular levels from rat nucleus 
      accumbens: shell/core differences.
PG  - 187-92
LID - 10.1016/j.neuint.2009.02.014 [doi]
AB  - Salsolinol (SAL), a condensation product of dopamine and acetaldehyde that 
      appears in the rat and human brain after ethanol ingestion, has been largely 
      implicated in the aetiology of alcoholism. Although the behavioural consequences 
      of systemic or intracerebral SAL administrations have been described, the 
      neurochemical effects of pharmacologically relevant doses of SAL and other 
      tetrahydroisoquinolines (THIQs) in the brain areas involved in alcohol addiction 
      are practically unknown. To gain an insight into this topic, male Wistar rats 
      were stereotaxically implanted with one concentric microdialysis probe in either 
      the shell or the core of the nucleus accumbens (NAc). Treatments involved local 
      administration of 0.1, 5 and 25 microM SAL for 20 min through the dialysis probe. 
      Dopamine (DA) concentrations in the shell or core of the NAc were on-line 
      analyzed every 20 min by HPLC with electrochemical detection. Implantation of the 
      probe was histologically evaluated at the end of the experiments. Our results 
      indicate that dialysis application of 5 and 25 microM SAL into the core increased 
      the dialysate levels of DA. Conversely, the administration of the same doses of 
      this drug into the shell significantly reduced the DA levels in this subregion. 
      In conclusion, these data reveal that local application of SAL affects the DA 
      levels in the NAc subterritories in a region-specific manner. These findings may 
      prove useful in probing CNS sites and mechanisms involved in alcohol consumption.
FAU - Hipolito, Lucia
AU  - Hipolito L
AD  - Departamento de Farmacia y Tecnologia Farmaceutica, Universidad de Valencia, Avda 
      Vicente Andres Estelles s/n, 46100 Burjassot, Spain.
FAU - Sanchez-Catalan, Maria Jose
AU  - Sanchez-Catalan MJ
FAU - Granero, Luis
AU  - Granero L
FAU - Polache, Ana
AU  - Polache A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090305
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Isoquinolines)
RN  - 3K9958V90M (Ethanol)
RN  - 9ILS801M65 (salsolinol)
RN  - GO1N1ZPR3B (Acetaldehyde)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Acetaldehyde/metabolism
MH  - Alcohol-Induced Disorders, Nervous System/metabolism/physiopathology
MH  - Alcoholism/metabolism/physiopathology
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Dopamine/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Down-Regulation/drug effects/physiology
MH  - Ethanol/metabolism
MH  - Extracellular Fluid/*drug effects/*metabolism
MH  - Isoquinolines/*pharmacology
MH  - Male
MH  - Microdialysis
MH  - Nucleus Accumbens/cytology/*drug effects/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reward
MH  - Synaptic Transmission/drug effects/physiology
MH  - Up-Regulation/drug effects/physiology
EDAT- 2009/06/16 09:00
MHDA- 2009/09/03 06:00
CRDT- 2009/06/16 09:00
PHST- 2008/12/23 00:00 [received]
PHST- 2009/02/17 00:00 [revised]
PHST- 2009/02/25 00:00 [accepted]
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/09/03 06:00 [medline]
AID - S0197-0186(09)00081-3 [pii]
AID - 10.1016/j.neuint.2009.02.014 [doi]
PST - ppublish
SO  - Neurochem Int. 2009 Sep;55(4):187-92. doi: 10.1016/j.neuint.2009.02.014. Epub 
      2009 Mar 5.