PMID- 19524462
OWN - NLM
STAT- MEDLINE
DCOM- 20090827
LR  - 20151119
IS  - 1532-2165 (Electronic)
IS  - 1078-5884 (Linking)
VI  - 38
IP  - 3
DP  - 2009 Sep
TI  - Muscle mitochondrial function in patients with type 2 diabetes mellitus and 
      peripheral arterial disease: implications in vascular surgery.
PG  - 356-64
LID - 10.1016/j.ejvs.2009.04.014 [doi]
AB  - OBJECTIVES: (1) To review the available information on mitochondrial function in 
      type 2 diabetes mellitus (T2DM) and peripheral arterial disease (PAD) obtained by 
      non-invasive phosphorus magnetic resonance spectroscopy ((31)PMRS), near-infrared 
      spectroscopy (NIRS) in vivo and respirometry on mitochondria isolated from muscle 
      biopsies in vitro (2) to evaluate the usefulness of such data in the diagnosis, 
      treatment and prognosis of these patients. DESIGN: Review. SEARCH STRATEGY: 
      PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and manual literature search. MAIN 
      RESULTS: Fifty-three articles were retrieved, which included (31)PMRS, 15, NIRS, 
      11, Combined, 1 and Respirometry, 2 and background literature, 24. CONCLUSION: 
      Muscle mitochondrial function is impaired in both T2DM and PAD patients, but 
      differently. Patients suffering from both pathological conditions will display 
      more serious impairment of the mitochondrial function. Mitochondrial function and 
      the degree of ischaemic disease as evaluated by (31)PMRS and NIRS are well 
      correlated. The NIRS technique appears to determine the degree of PAD better than 
      (31)PMRS. It is argued that systematic testing of mitochondrial function may be a 
      useful prognostic tool with PAD and T2DM, but clinical studies are needed.
FAU - Pedersen, B L
AU  - Pedersen BL
AD  - Department of Vascular Surgery, Gentofte Hospital, Niels Andersens Vej 65, 2900 
      Hellerup, Denmark. brlipe01@geh.regionh.dk
FAU - Baekgaard, N
AU  - Baekgaard N
FAU - Quistorff, B
AU  - Quistorff B
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090612
PL  - England
TA  - Eur J Vasc Endovasc Surg
JT  - European journal of vascular and endovascular surgery : the official journal of 
      the European Society for Vascular Surgery
JID - 9512728
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Biopsy
MH  - Cell Respiration
MH  - Chronic Disease
MH  - Diabetes Mellitus, Type 2/*complications/metabolism/surgery
MH  - Diabetic Angiopathies/diagnosis/etiology/*metabolism/surgery
MH  - Humans
MH  - Ischemia/diagnosis/etiology/*metabolism/surgery
MH  - Magnetic Resonance Spectroscopy
MH  - Mitochondria, Muscle/*metabolism
MH  - Muscle, Skeletal/*metabolism
MH  - Oxygen Consumption
MH  - Peripheral Vascular Diseases/diagnosis/etiology/*metabolism/surgery
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Spectroscopy, Near-Infrared
MH  - *Vascular Surgical Procedures
RF  - 53
EDAT- 2009/06/16 09:00
MHDA- 2009/08/28 09:00
CRDT- 2009/06/16 09:00
PHST- 2009/04/20 00:00 [received]
PHST- 2009/04/20 00:00 [accepted]
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/08/28 09:00 [medline]
AID - S1078-5884(09)00231-7 [pii]
AID - 10.1016/j.ejvs.2009.04.014 [doi]
PST - ppublish
SO  - Eur J Vasc Endovasc Surg. 2009 Sep;38(3):356-64. doi: 10.1016/j.ejvs.2009.04.014. 
      Epub 2009 Jun 12.