PMID- 19524640
OWN - NLM
STAT- MEDLINE
DCOM- 20090923
LR  - 20131121
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 461
IP  - 2
DP  - 2009 Sep 18
TI  - NR2A/B-containing NMDA receptors mediate cocaine-induced synaptic plasticity in 
      the VTA and cocaine psychomotor sensitization.
PG  - 159-62
LID - 10.1016/j.neulet.2009.06.002 [doi]
AB  - Cocaine-induced modifications of glutamatergic synaptic transmission in the 
      mesolimbic system play a key role in adaptations that promote addictive 
      behaviors. In particular, the activation of ionotropic glutamate 
      N-methyl-D-aspartate receptor (NMDAR) in the ventral tegmental area (VTA) is 
      critical for both cocaine-induced synaptic plasticity induced by a single cocaine 
      injection and for the initiation of cocaine psychomotor sensitization. In this 
      study, we set to determine whether the NR2 subunits of the NMDAR play a specific 
      role in triggering cocaine-induced alterations in synaptic plasticity and the 
      development of psychomotor sensitization. We found that inhibition of 
      NR2A-containing NMDARs by NVP-AAM077, or NR2B-containing receptors by ifenprodil, 
      blocked cocaine-induced increase in the AMPAR/NMDAR currents ratio, a measure of 
      long-term potentiation (LTP) in vivo, in VTA neurons 24h following a single 
      cocaine injection. Furthermore, inhibition of the NR2A subunit during the 
      development of psychomotor sensitization attenuated the enhanced locomotor 
      activity following repeated cocaine injections. Together, these results suggest 
      that NR2-containing NMDA receptors play an important role in the machinery that 
      triggers synaptic and behavioral adaptations to drugs of abuse such as cocaine.
FAU - Schumann, Johanna
AU  - Schumann J
AD  - Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew 
      University of Jerusalem, Jerusalem 91120, Israel.
FAU - Matzner, Henry
AU  - Matzner H
FAU - Michaeli, Avner
AU  - Michaeli A
FAU - Yaka, Rami
AU  - Yaka R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090612
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (NR2A NMDA receptor)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Protein Subunits)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cocaine/*pharmacology
MH  - Male
MH  - Motor Activity/drug effects
MH  - Neuronal Plasticity
MH  - Protein Subunits/antagonists & inhibitors/physiology
MH  - Psychomotor Performance/*drug effects
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*physiology
MH  - Synapses/*physiology
MH  - Ventral Tegmental Area/*physiology
EDAT- 2009/06/16 09:00
MHDA- 2009/09/24 06:00
CRDT- 2009/06/16 09:00
PHST- 2009/05/18 00:00 [received]
PHST- 2009/06/02 00:00 [accepted]
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/09/24 06:00 [medline]
AID - S0304-3940(09)00767-8 [pii]
AID - 10.1016/j.neulet.2009.06.002 [doi]
PST - ppublish
SO  - Neurosci Lett. 2009 Sep 18;461(2):159-62. doi: 10.1016/j.neulet.2009.06.002. Epub 
      2009 Jun 12.