PMID- 19524809
OWN - NLM
STAT- MEDLINE
DCOM- 20090820
LR  - 20090615
IS  - 0761-8417 (Print)
IS  - 0761-8417 (Linking)
VI  - 65
IP  - 3
DP  - 2009 Jun
TI  - [Predictive factors for acute radiation pneumonitis].
PG  - 177-86
LID - 10.1016/j.pneumo.2009.03.011 [doi]
AB  - Thoracic irradiation is a major weapon in the treatment of nonmetastatic primary 
      lung cancer, in particular in patients presenting a locally advanced disease of 
      the mediastinium. Acute radiation pneumonitis (ARP) is one of the main limiting 
      toxicities. The purpose of this work is to sum up the current state of knowledge 
      of the factors of risk of developing ARP. The incidence after conventional 
      irradiation, in patients with non small cell lung cancer (NSCLC) is about 7 to 
      10% in the moderate although symptomatic forms of ARP and about 1 to 3% in the 
      severe forms. The factors related to the patient, the tumour or treatments prior 
      to the irradiation do not determine any specific risk of ARP besides an age of 
      over 65 years that remains debatable. The validated predictive factors of ARP are 
      mainly related to the irradiation factors (healthy lung volumes irradiated, 
      average dose of irradiation, etc.). Nevertheless, in spite of the adjustment of 
      these parameters, the individual susceptibility to the toxicity of thoracic 
      radiotherapy remains significant, directing current research to the biological 
      markers intrinsic to the patient. In particular, the involvement of early 
      variations of certain cytokines (IL-6, IL-10, TGF-ss) in the occurrence of ARP 
      during irradiation has been suggested and studies are under way to confirm their 
      involvement and determine their role.
FAU - Arpin, D
AU  - Arpin D
AD  - Service de pneumologie, hopital de la Croix-Rousse, hospices civils de Lyon, 103, 
      grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France. 
      dominique.arpin@chu-lyon.fr <dominique.arpin@chu-lyon.fr>
FAU - Mahe, M-A
AU  - Mahe MA
FAU - Servois, V
AU  - Servois V
FAU - Claude, L
AU  - Claude L
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Facteurs predictifs de la pneumopathie radique aigue.
DEP - 20090603
PL  - France
TA  - Rev Pneumol Clin
JT  - Revue de pneumologie clinique
JID - 8406312
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/adverse effects
MH  - Humans
MH  - Neoplasms/drug therapy/radiotherapy
MH  - Radiation Pneumonitis/*diagnosis/*therapy
MH  - Radiotherapy Dosage
MH  - Risk Factors
RF  - 69
EDAT- 2009/06/16 09:00
MHDA- 2009/08/21 09:00
CRDT- 2009/06/16 09:00
PHST- 2008/09/05 00:00 [received]
PHST- 2009/03/25 00:00 [revised]
PHST- 2009/03/26 00:00 [accepted]
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/08/21 09:00 [medline]
AID - S0761-8417(09)00074-1 [pii]
AID - 10.1016/j.pneumo.2009.03.011 [doi]
PST - ppublish
SO  - Rev Pneumol Clin. 2009 Jun;65(3):177-86. doi: 10.1016/j.pneumo.2009.03.011. Epub 
      2009 Jun 3.