PMID- 19525682
OWN - NLM
STAT- MEDLINE
DCOM- 20090817
LR  - 20181201
IS  - 1538-4683 (Electronic)
IS  - 1061-5377 (Linking)
VI  - 17
IP  - 4
DP  - 2009 Jul-Aug
TI  - Drug interaction between clopidogrel and proton pump inhibitors.
PG  - 198-200
LID - 10.1097/CRD.0b013e3181a857ba [doi]
AB  - Dual antiplatelet therapy with clopidogrel and aspirin has been shown to reduce 
      recurrent cardiac events in patients with acute coronary syndromes or those who 
      have undergone coronary artery stent placement. Clopidogrel, a thienopyridine, is 
      a prodrug that is transformed in vivo to an active metabolite by the cytochrome 
      P450 enzyme system. Due to the increased risk of bleeding in patients on dual 
      antiplatelet therapy, concomitant gastrointestinal ulcer prophylaxis with a 
      proton pump inhibitor (PPI) is frequently prescribed. Data from recent studies 
      show that PPIs, which are extensively metabolized by the cytochrome system, may 
      decrease the antiplatelet activity of clopidogrel. This article reviews the 
      metabolism of various PPIs and existing data regarding the drug-drug interaction 
      between PPIs and clopidogrel.
FAU - Khalique, Saira Chand
AU  - Khalique SC
AD  - Department of Pharmacy, Montefiore Medical Center, Bronx, New York, USA.
FAU - Cheng-Lai, Angela
AU  - Cheng-Lai A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cardiol Rev
JT  - Cardiology in review
JID - 9304686
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - A74586SNO7 (Clopidogrel)
RN  - OM90ZUW7M1 (Ticlopidine)
SB  - IM
MH  - Clopidogrel
MH  - Cytochrome P-450 Enzyme System/metabolism
MH  - *Drug Interactions
MH  - Humans
MH  - Platelet Aggregation Inhibitors/metabolism/*pharmacology
MH  - Proton Pump Inhibitors/metabolism/*pharmacology
MH  - Ticlopidine/*analogs & derivatives/metabolism/pharmacology
RF  - 22
EDAT- 2009/06/16 09:00
MHDA- 2009/08/18 09:00
CRDT- 2009/06/16 09:00
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/08/18 09:00 [medline]
AID - 00045415-200908000-00007 [pii]
AID - 10.1097/CRD.0b013e3181a857ba [doi]
PST - ppublish
SO  - Cardiol Rev. 2009 Jul-Aug;17(4):198-200. doi: 10.1097/CRD.0b013e3181a857ba.