PMID- 19525727
OWN - NLM
STAT- MEDLINE
DCOM- 20090908
LR  - 20211020
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Print)
IS  - 1057-0829 (Linking)
VI  - 18
IP  - 5
DP  - 2009 Jun-Jul
TI  - Imaging of optic nerve head drusen: improvements with spectral domain optical 
      coherence tomography.
PG  - 373-8
LID - 10.1097/IJG.0b013e31818624a4 [doi]
AB  - OBJECTIVE: To demonstrate a new algorithm that can determine the shape, location, 
      and volume of optic nerve head drusen (ONHD), which were imaged with spectral 
      domain optical coherence tomography (SDOCT). METHODS: One exenteration patient 
      and 4 glaucoma patients with bilateral ONHD were recruited from the Massachusetts 
      Eye and Ear Infirmary and from a private practice office. Images were obtained 
      using an experimental SDOCT system developed at the Wellman Center for 
      Photomedicine, Massachusetts General Hospital. With axial resolutions of about 6 
      mum, SDOCT can obtain 2-dimensional images in 1/29 of a second, compared with 
      commercially available time domain OCT instruments with 10 mum resolution images 
      in 1.28 seconds. The volumes of ONHD were calculated with a new algorithm and 
      were then correlated with visual field mean deviation. RESULTS: SDOCT can display 
      2-dimensional images comparable with histology and 3-dimensional videos of ONHD. 
      ONHD are signal-poor regions with high-signaled borders. Larger ONHD volumes are 
      directly correlated with larger mean deviation absolute values on Humphrey visual 
      field testing. CONCLUSIONS: SDOCT is a potentially better technique for ONHD 
      imaging and may improve the diagnosis and management of patients with both OHND 
      and glaucoma.
FAU - Yi, Kayoung
AU  - Yi K
AD  - Harvard Medical School, Department of Ophthalmology, Glaucoma Service, 
      Massachusetts General Hospital, Boston, MA, USA.
FAU - Mujat, Mircea
AU  - Mujat M
FAU - Sun, Wei
AU  - Sun W
FAU - Burnes, Daina
AU  - Burnes D
FAU - Latina, Mark A
AU  - Latina MA
FAU - Lin, Derrick T
AU  - Lin DT
FAU - Deschler, Daniel G
AU  - Deschler DG
FAU - Rubin, Peter A D
AU  - Rubin PA
FAU - Park, Boris Hyle
AU  - Park BH
FAU - de Boer, Johannes F
AU  - de Boer JF
FAU - Chen, Teresa C
AU  - Chen TC
LA  - eng
GR  - EY 014104/EY/NEI NIH HHS/United States
GR  - R01 EY 014975/EY/NEI NIH HHS/United States
GR  - R01 EY014975-02/EY/NEI NIH HHS/United States
GR  - R01 EY014975/EY/NEI NIH HHS/United States
GR  - P30 EY014104/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Aged
MH  - *Algorithms
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Male
MH  - Middle Aged
MH  - Optic Disk Drusen/complications/*diagnosis
MH  - Tomography, Optical Coherence/*methods/standards
MH  - Vision Disorders/diagnosis/etiology
MH  - Visual Field Tests/methods
MH  - Visual Fields
PMC - PMC2697454
MID - NIHMS85785
EDAT- 2009/06/16 09:00
MHDA- 2009/09/09 06:00
PMCR- 2010/06/01
CRDT- 2009/06/16 09:00
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/09/09 06:00 [medline]
PHST- 2010/06/01 00:00 [pmc-release]
AID - 00061198-200906000-00005 [pii]
AID - 10.1097/IJG.0b013e31818624a4 [doi]
PST - ppublish
SO  - J Glaucoma. 2009 Jun-Jul;18(5):373-8. doi: 10.1097/IJG.0b013e31818624a4.