PMID- 19525875
OWN - NLM
STAT- MEDLINE
DCOM- 20091016
LR  - 20090727
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 49
IP  - 2
DP  - 2009 Aug
TI  - Defining eosinophilic colitis in children: insights from a retrospective case 
      series.
PG  - 208-15
LID - 10.1097/MPG.0b013e31818de373 [doi]
AB  - OBJECTIVES: Although it is a well-described syndrome in infants, eosinophilic 
      colitis is a loosely defined and poorly understood diagnosis in older children. 
      The aims of this case series were to characterise colonic eosinophilia in 
      children and to determine whether it represents a distinct clinicopathological 
      condition. METHODS: We retrospectively reviewed symptomatic children older than 
      12 months with the principal diagnosis of colonic eosinophilia who presented 
      between January 2000 and February 2007 (n = 38) and a further 10 children whose 
      colonic biopsies were reported as histologically normal. The eosinophil density 
      in all available gastrointestinal biopsies (n = 620) of these children was 
      determined using a validated quantitative morphometric method. Patients were 
      subdivided according to mean colonic eosinophil levels into 3 groups (marked, 
      moderate, or minimal colonic eosinophilia). The following patient information was 
      obtained and compared among patient groups: symptoms prompting endoscopy, atopic 
      history, outcome, serum C-reactive protein and total immunoglobulin E (IgE) 
      levels, erythrocyte sedimentation rate, blood eosinophil count, and endoscopic 
      findings. RESULTS: In all 3 patient groups, there was a colonic gradient of 
      decreasing eosinophil density from caecum to rectum. Upper gastrointestinal tract 
      biopsies did not exhibit eosinophilia. Although a significant association (P = 
      0.03) between abnormal total IgE levels and moderate or severe colonic 
      eosinophilia was found, there was no significant difference (P > 0.05) in other 
      patient characteristics. Furthermore, follow-up data did not show a consistent 
      relation between eosinophil density and progression of symptoms. CONCLUSIONS: We 
      find no association between "eosinophilic colitis," defined as a histologically 
      demonstrated marked colonic eosinophilia, and symptoms, history of atopy, 
      inflammatory markers, or clinical outcome.
FAU - Behjati, Sam
AU  - Behjati S
AD  - Department of Histopathology, Royal Free Hampstead NHS Trust, Royal Free and 
      University College Medical School Pond Street, London, UK.
FAU - Zilbauer, Matthias
AU  - Zilbauer M
FAU - Heuschkel, Robert
AU  - Heuschkel R
FAU - Phillips, Alan
AU  - Phillips A
FAU - Salvestrini, Camilla
AU  - Salvestrini C
FAU - Torrente, Franco
AU  - Torrente F
FAU - Bates, Alan W
AU  - Bates AW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Colitis, Microscopic/*diagnosis/immunology
MH  - Colon/*immunology
MH  - Eosinophilia/blood/*diagnosis
MH  - *Eosinophils
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Retrospective Studies
EDAT- 2009/06/16 09:00
MHDA- 2009/10/17 06:00
CRDT- 2009/06/16 09:00
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/10/17 06:00 [medline]
AID - 10.1097/MPG.0b013e31818de373 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2009 Aug;49(2):208-15. doi: 
      10.1097/MPG.0b013e31818de373.