PMID- 19525881
OWN - NLM
STAT- MEDLINE
DCOM- 20091117
LR  - 20161125
IS  - 1473-5628 (Electronic)
IS  - 0143-3636 (Linking)
VI  - 30
IP  - 9
DP  - 2009 Sep
TI  - Chronic effects of dietary carbohydrate variation on 
      [18F]-2-fluoro-2-deoxyglucose uptake in rodent heart.
PG  - 675-80
LID - 10.1097/MNM.0b013e32832aa6e8 [doi]
AB  - PURPOSE: Measured cardiac [F]-2-fluoro-2-deoxyglucose (FDG) activity in human PET 
      scans is variable despite efforts to standardize patient preparation. Heart 
      uptake can obscure chest disease, and is of physiologic interest. Short-term 
      carbohydrate (CHO) restriction can reduce FDG uptake, although unreliably, 
      whereas long-term restriction of CHO has not been systematically studied. It 
      would be valuable to understand FDG hearts' chronic dietary dependence. METHODS: 
      Fifteen Wistar rats (age 4 weeks) were randomized to three diet groups (n = 5) of 
      low (0.1% of total energy), intermediate (52%), and high (78%) CHO content (LC, 
      IC, and HC, respectively). After 4 weeks, blood for ketone bodies (KB), glucose, 
      insulin, and glucagon was obtained, followed in 2 days by whole-body PET with 37 
      MBq FDG. Diet groups were switched every 4 weeks to control for the effects of 
      dietary order. Heart maximal standardized uptake value was compared among 
      animals. RESULTS: Heart mean maximal standardized uptake value was dramatically 
      reduced for LC (3.4+/-0.4; P<0.001) compared with either IC (10.9+/-0.7) or HC 
      (11.0+/-0.7) (P=NS, IC vs. HC). KB (mumol/l) differed widely (P<0.001) in LC 
      (718.6+/-40.0) versus IC (120.3+/-34.0) and HC (99.2+/-32.1) (P=NS, IC vs. HC), 
      whereas glucose, insulin, and glucagon did not differ among the groups. 
      CONCLUSION: Sustained CHO-restriction results in marked, reproducibly reduced 
      cardiac FDG uptake. Six-fold to seven-fold increased KB concentrations provide 
      alternative substrate to glucose.
FAU - Fine, Eugene J
AU  - Fine EJ
AD  - Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 
      10461, USA. efine@aecom.yu.edu
FAU - Miao, Weibing
AU  - Miao W
FAU - Koba, Wade
AU  - Koba W
FAU - Volek, Jeff S
AU  - Volek JS
FAU - Blaufox, M Donald
AU  - Blaufox MD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nucl Med Commun
JT  - Nuclear medicine communications
JID - 8201017
RN  - 0 (Dietary Carbohydrates)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Animals
MH  - Blood Chemical Analysis
MH  - Body Weight/drug effects
MH  - Brain/drug effects/metabolism
MH  - Dietary Carbohydrates/*pharmacology
MH  - Fluorodeoxyglucose F18/*metabolism
MH  - Heart/*diagnostic imaging/*drug effects
MH  - Myocardium/*metabolism
MH  - Positron-Emission Tomography
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
EDAT- 2009/06/16 09:00
MHDA- 2009/11/18 06:00
CRDT- 2009/06/16 09:00
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/11/18 06:00 [medline]
AID - 10.1097/MNM.0b013e32832aa6e8 [doi]
PST - ppublish
SO  - Nucl Med Commun. 2009 Sep;30(9):675-80. doi: 10.1097/MNM.0b013e32832aa6e8.