PMID- 19525929
OWN - NLM
STAT- MEDLINE
DCOM- 20091110
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Linking)
VI  - 22
IP  - 9
DP  - 2009 Sep
TI  - Pseudosarcomatous fibroblastic/myofibroblastic proliferation in perinephric 
      adipose tissue adjacent to renal cell carcinoma: a lesion mimicking 
      well-differentiated liposarcoma.
PG  - 1196-200
LID - 10.1038/modpathol.2009.84 [doi]
AB  - Cytologically atypical stromal cells were found in the perinephric adipose 
      tissue, mimicking well-differentiated liposarcoma in 12 of 59 (20%) consecutive 
      nephrectomy specimens that were resected for renal cell carcinoma. 
      Morphologically, the atypical cells included enlarged, hyperchromatic spindle 
      cells and floret-type multinucleate cells. Of 59, 10 (17%) renal cell carcinomas 
      invaded through the renal capsule into the perinephric adipose tissue. Of these 
      cases, three (30%) contained the aforementioned atypical cells. In contrast, 9 of 
      49 cases without extrarenal invasion (18%) contained the atypical stromal cells. 
      Of the 12 cases with atypical stromal cells, 3 (25%) were associated with 
      extrarenal involvement. The atypical spindle cells exhibited focal to variable 
      positivity for smooth muscle actin and desmin in 3 of the 14 cases (including two 
      cases from our consultation files) each. Cytokeratin AE1/AE3, cytokeratin Cam 
      5.2, cytokeratin 7, epithelial membrane antigen, and S-100 were negative in all 
      cases. Amplification of MDM2 gene region, which is commonly observed in 
      well-differentiated liposarcoma, was absent by fluorescence in situ hybridization 
      (FISH) in the atypical stromal cells. Immunohistochemistry and FISH suggest that 
      the atypical cells are most consistent with reactive fibroblasts/myofibroblasts. 
      Recognition of these atypical fibroblasts/myofibroblasts may help in avoiding the 
      potential pitfall of misdiagnosing them as well-differentiated liposarcoma.
FAU - Tanas, Munir R
AU  - Tanas MR
AD  - Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, 
      The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine, Case 
      Western Reserve University, Cleveland, OH 44195, USA.
FAU - Sthapanachai, Chalenpoj
AU  - Sthapanachai C
FAU - Nonaka, Daisuke
AU  - Nonaka D
FAU - Melamed, Jonathan
AU  - Melamed J
FAU - Oliveira, Andre M
AU  - Oliveira AM
FAU - Erickson-Johnson, Michele R
AU  - Erickson-Johnson MR
FAU - Rubin, Brian P
AU  - Rubin BP
LA  - eng
PT  - Journal Article
DEP - 20090612
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adipose Tissue/pathology
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma, Renal Cell/metabolism/*pathology
MH  - Diagnosis, Differential
MH  - Fibroblasts/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/metabolism/*pathology
MH  - Liposarcoma/*pathology
EDAT- 2009/06/16 09:00
MHDA- 2009/11/11 06:00
CRDT- 2009/06/16 09:00
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/11/11 06:00 [medline]
AID - S0893-3952(22)02471-1 [pii]
AID - 10.1038/modpathol.2009.84 [doi]
PST - ppublish
SO  - Mod Pathol. 2009 Sep;22(9):1196-200. doi: 10.1038/modpathol.2009.84. Epub 2009 
      Jun 12.