PMID- 19526280
OWN - NLM
STAT- MEDLINE
DCOM- 20100125
LR  - 20211020
IS  - 1476-3524 (Electronic)
IS  - 1029-8428 (Print)
IS  - 1029-8428 (Linking)
VI  - 16
IP  - 3
DP  - 2009 Oct
TI  - Commentary: Regulating proNGF action: multiple targets for therapeutic 
      intervention.
PG  - 255-60
LID - 10.1007/s12640-009-9054-9 [doi]
AB  - Neurotrophins are initially synthesized as precursor forms that are cleaved to 
      release C-terminal mature forms that bind to Trk receptors to initiate survival 
      and differentiative responses. Recent studies suggest that the precursor form of 
      NGF (proNGF) acts as a distinct ligand by binding to a receptor complex of p75 
      and sortilin to initiate cell death. Induction of proNGF and p75 has been 
      observed in multiple pathological states and injury models in the central nervous 
      system, and blockade of proNGF/p75 interaction is efficacious in limiting 
      neuronal apoptosis. Multiple strategies that may act to limit proNGF action are 
      considered as potential therapeutic targets for future development.
FAU - Hempstead, Barbara L
AU  - Hempstead BL
AD  - Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, 
      NY 10065, USA. blhempst@med.cornell.edu
LA  - eng
GR  - R01 NS030687-15/NS/NINDS NIH HHS/United States
GR  - NS30687/NS/NINDS NIH HHS/United States
GR  - R01 NS030687-16/NS/NINDS NIH HHS/United States
GR  - R01 NS030687-17/NS/NINDS NIH HHS/United States
GR  - R01 NS030687/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090428
PL  - United States
TA  - Neurotox Res
JT  - Neurotoxicity research
JID - 100929017
RN  - 0 (Adaptor Proteins, Vesicular Transport)
RN  - 0 (Protein Precursors)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 0 (pro-nerve growth factor, human)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - Z020Y8WIJ4 (sortilin)
SB  - IM
MH  - Adaptor Proteins, Vesicular Transport/pharmacology
MH  - Animals
MH  - Cell Death/drug effects/physiology
MH  - Central Nervous System Diseases/*metabolism/*therapy
MH  - Disease Models, Animal
MH  - Gene Expression Regulation/physiology
MH  - Humans
MH  - Nerve Growth Factor/antagonists & inhibitors/genetics/*metabolism
MH  - Protein Precursors/antagonists & inhibitors/genetics/*metabolism
MH  - Receptor, Nerve Growth Factor/genetics/metabolism
PMC - PMC3091386
MID - NIHMS127056
EDAT- 2009/06/16 09:00
MHDA- 2010/01/26 06:00
PMCR- 2011/05/10
CRDT- 2009/06/16 09:00
PHST- 2009/02/27 00:00 [received]
PHST- 2009/04/03 00:00 [accepted]
PHST- 2009/03/23 00:00 [revised]
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2010/01/26 06:00 [medline]
PHST- 2011/05/10 00:00 [pmc-release]
AID - 10.1007/s12640-009-9054-9 [doi]
PST - ppublish
SO  - Neurotox Res. 2009 Oct;16(3):255-60. doi: 10.1007/s12640-009-9054-9. Epub 2009 
      Apr 28.