PMID- 19526317
OWN - NLM
STAT- MEDLINE
DCOM- 20090924
LR  - 20211020
IS  - 1567-2387 (Electronic)
IS  - 1567-2379 (Linking)
VI  - 40
IP  - 2
DP  - 2009 Apr
TI  - p63 Immunoexpression in lip carcinogenesis.
PG  - 131-7
LID - 10.1007/s10735-009-9223-4 [doi]
AB  - Actinic cheilitis (AC) is a potentially malignant disorder, which can present 
      degrees of epithelial dysplasia, and may even evolve into lip squamous cell 
      carcinoma (LSCC). Since p63 is a protein homologous to p53, which can be 
      associated with tumorigenesis in epithelial tissues, this study aims to evaluate 
      it in AC and LSCC, in the hopes to estimate the biological behavior of these 
      lesions. Forty AC lesions and sixty-five cases of LSCC were quantitatively 
      analyzed by immunohistochemistry, using anti-p63 antibody with ten cases of 
      normal lip mucosa used as a control group. In all AC and LSCC cases studied, it 
      was possible to detect the presence of the p63 protein. There was no 
      statistically significant difference between immunostained cells and degree of 
      epithelial dysplasias, nor between the LSCC grading malignancy. Nevertheless, p63 
      immunoexpression showed to be significantly correlated with AC and LSCC lesions 
      as compared to normal lip epithelium. The results indicate that p63 protein is 
      consistently expressed in AC and LSCC, and might be of help in the differential 
      diagnosis between normal and dysplastic/neoplastic epithelium, although the 
      evaluation using a primary antibody to all isotypes did not prove to be a risk 
      biomarker during lip carcinogenesis. Thus, the production of antibodies for the 
      six different p63 isotypes is urged, since in isolation they can have predictive 
      value, mainly the DeltaNp63 isoforms.
FAU - Xavier, Flavia Calo Aquino
AU  - Xavier FC
AD  - Integrated Clinic and Propedeutics Department, School of Dentistry, Federal 
      University of Bahia, Araujo Pinho, 62/64 Canela, Salvador, BA 40110-150, Brazil. 
      f.calo@uol.com.br
FAU - Takiya, Christina Maeda
AU  - Takiya CM
FAU - Reis, Silvia Regina Almeida
AU  - Reis SR
FAU - Ramalho, Luciana Maria Pedreira
AU  - Ramalho LM
LA  - eng
PT  - Journal Article
DEP - 20090613
PL  - Netherlands
TA  - J Mol Histol
JT  - Journal of molecular histology
JID - 101193653
RN  - 0 (CKAP4 protein, human)
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Cheilitis/*metabolism
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - In Vitro Techniques
MH  - Lip Neoplasms/*metabolism
MH  - Membrane Proteins/*metabolism
EDAT- 2009/06/16 09:00
MHDA- 2009/09/25 06:00
CRDT- 2009/06/16 09:00
PHST- 2009/03/09 00:00 [received]
PHST- 2009/05/29 00:00 [accepted]
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2009/09/25 06:00 [medline]
AID - 10.1007/s10735-009-9223-4 [doi]
PST - ppublish
SO  - J Mol Histol. 2009 Apr;40(2):131-7. doi: 10.1007/s10735-009-9223-4. Epub 2009 Jun 
      13.