PMID- 19527229
OWN - NLM
STAT- MEDLINE
DCOM- 20090818
LR  - 20181201
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 62
IP  - 1
DP  - 2009 Jul
TI  - HLA-G expression is up-regulated by progesterone in mesenchymal stem cells.
PG  - 25-33
LID - 10.1111/j.1600-0897.2009.00707.x [doi]
AB  - PROBLEM: Maternal immune response to fetal tissues is modified in such way that 
      it favors the development of pregnancy. Human leukocyte antigen (HLA)-G, 
      progesterone and mesenchymal stem cells (MSCs) have been identified as potent 
      immunomodulatory agents in different experimental systems and the interactions 
      between these three factors are studies in this paper. METHOD OF STUDY: Human 
      MSCs are isolated from human adipose tissue, bone marrow and decidua are cultured 
      in the presence of progesterone and the expression of HLA-G is followed-up at 
      protein and mRNA levels. RESULTS: The MSCs cultured in the presence of 
      progesterone express increased levels of both cell surface and cytoplasmic HLA-G 
      when compared with the control MSCs. CONCLUSION: Progesterone up-regulates the 
      expression by MSCs of HLA-G which is a major player in maintenance of the immune 
      balance between the mother and the fetus. MSCs are newly detected targets of 
      progesterone with well documented immunomodulatory activity.
FAU - Ivanova-Todorova, Ekaterina
AU  - Ivanova-Todorova E
AD  - Laboratory of Clinical Immunology, University Hospital St.I.Rilski, Medical 
      University Sofia, Sofia, Bulgaria.
FAU - Mourdjeva, Milena
AU  - Mourdjeva M
FAU - Kyurkchiev, Dobroslav
AU  - Kyurkchiev D
FAU - Bochev, Ivan
AU  - Bochev I
FAU - Stoyanova, Elena
AU  - Stoyanova E
FAU - Dimitrov, Rumen
AU  - Dimitrov R
FAU - Timeva, Tanya
AU  - Timeva T
FAU - Yunakova, Maria
AU  - Yunakova M
FAU - Bukarev, Dimitar
AU  - Bukarev D
FAU - Shterev, Atanas
AU  - Shterev A
FAU - Tivchev, Petar
AU  - Tivchev P
FAU - Kyurkchiev, Stanimir
AU  - Kyurkchiev S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Progestins)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Adipose Tissue/immunology/metabolism
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cells, Cultured
MH  - Decidua/immunology
MH  - Female
MH  - HLA Antigens/*biosynthesis
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*biosynthesis
MH  - Humans
MH  - Mesenchymal Stem Cells/drug effects/*immunology
MH  - Middle Aged
MH  - Pregnancy
MH  - Progesterone/*metabolism/pharmacology
MH  - Progestins/pharmacology
MH  - Up-Regulation
EDAT- 2009/06/17 09:00
MHDA- 2009/08/19 09:00
CRDT- 2009/06/17 09:00
PHST- 2009/06/17 09:00 [entrez]
PHST- 2009/06/17 09:00 [pubmed]
PHST- 2009/08/19 09:00 [medline]
AID - AJI707 [pii]
AID - 10.1111/j.1600-0897.2009.00707.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2009 Jul;62(1):25-33. doi: 10.1111/j.1600-0897.2009.00707.x.