PMID- 19527721
OWN - NLM
STAT- MEDLINE
DCOM- 20090909
LR  - 20090706
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Linking)
VI  - 583
IP  - 13
DP  - 2009 Jul 7
TI  - Excitatory amino acid transporter 2 associates with phosphorylated tau and is 
      localized in neurofibrillary tangles of tauopathic brains.
PG  - 2194-200
LID - 10.1016/j.febslet.2009.06.015 [doi]
AB  - Phosphorylated tau (p-tau) is the principal component of neurofibrillary tangles, 
      a pathological hallmark, and likely plays a neurotoxic role in tauopathies 
      including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and 
      corticobasal degeneration (CBD). We subjected brains from autopsy cases of AD, 
      PSP, and CBD to a variety of immunohistochemical, immunoblotting, and pull-down 
      assays. In this study, we show that excitatory amino acid transporter 2 (EAAT2) 
      preferentially interacted with phosphorylated tau and was localized in 
      neurofibrillary tangles in the brains of such patients. These results strongly 
      indicate that EAAT2 acts in tauopathy-related neurodegeneration, and 
      abnormalities in glutamate transport play an important role in the pathogenesis 
      of tauopathies.
FAU - Sasaki, Kumi
AU  - Sasaki K
AD  - Department of Neurology, Juntendo University, Urayasu Hospital, Tokyo, Japan.
FAU - Shimura, Hideki
AU  - Shimura H
FAU - Itaya, Masako
AU  - Itaya M
FAU - Tanaka, Ryota
AU  - Tanaka R
FAU - Mori, Hideo
AU  - Mori H
FAU - Mizuno, Yoshikuni
AU  - Mizuno Y
FAU - Kosik, Kenneth S
AU  - Kosik KS
FAU - Tanaka, Shigeki
AU  - Tanaka S
FAU - Hattori, Nobutaka
AU  - Hattori N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090613
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Excitatory Amino Acid Transporter 2)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amino Acid Sequence
MH  - Brain/*metabolism/pathology
MH  - Excitatory Amino Acid Transporter 2/*analysis/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Neurofibrillary Tangles/*metabolism
MH  - Tauopathies/*metabolism/pathology
MH  - tau Proteins/analysis/*metabolism
EDAT- 2009/06/17 09:00
MHDA- 2009/09/10 06:00
CRDT- 2009/06/17 09:00
PHST- 2009/05/07 00:00 [received]
PHST- 2009/06/02 00:00 [revised]
PHST- 2009/06/05 00:00 [accepted]
PHST- 2009/06/17 09:00 [entrez]
PHST- 2009/06/17 09:00 [pubmed]
PHST- 2009/09/10 06:00 [medline]
AID - S0014-5793(09)00461-X [pii]
AID - 10.1016/j.febslet.2009.06.015 [doi]
PST - ppublish
SO  - FEBS Lett. 2009 Jul 7;583(13):2194-200. doi: 10.1016/j.febslet.2009.06.015. Epub 
      2009 Jun 13.