PMID- 19535202
OWN - NLM
STAT- MEDLINE
DCOM- 20100107
LR  - 20180815
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 286
IP  - 2
DP  - 2009 Dec 28
TI  - Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7.
PG  - 189-95
LID - 10.1016/j.canlet.2009.05.025 [doi]
AB  - Interleukin-18 (IL-18) has recently been shown to have a pro-cancer effect in 
      various cancers. Increased serum levels of both IL-18 and transferrin in cancer 
      patients are correlated with its malignancy. However, the relationship between 
      transferrin and IL-18 is not well understood. Here, we show that exogenous 
      transferrin enhanced breast cancer cell proliferation and the proliferation rate 
      was reduced when endogenous transferrin expression was inhibited by transferrin 
      siRNA. The expression of endogenous transferrin was found to be regulated by 
      IL-18. Furthermore, we found that the MAPK pathway is involved in IL-18-induced 
      transferrin production. In conclusion, IL-18 is suggested as an inducer of 
      endogenous transferrin expression in breast cancer cells.
FAU - Park, Sunyoung
AU  - Park S
AD  - Department of Life Science, Sookmyung Women's University, Yongsan-gu, Seoul, 
      Republic of Korea.
FAU - Yoon, Sun Young
AU  - Yoon SY
FAU - Kim, Kyung-Eun
AU  - Kim KE
FAU - Lee, Ha Reum
AU  - Lee HR
FAU - Hur, Dae Young
AU  - Hur DY
FAU - Song, Hyunkeun
AU  - Song H
FAU - Kim, Daejin
AU  - Kim D
FAU - Bang, Sa Ik
AU  - Bang SI
FAU - Cho, Dae-Ho
AU  - Cho DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090616
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Flavonoids)
RN  - 0 (Interleukin-18)
RN  - 0 (Transferrin)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - SJE1IO5E3I (2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one)
SB  - IM
MH  - Blotting, Western
MH  - Breast Neoplasms/genetics/metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/*drug effects
MH  - Female
MH  - Flavonoids/pharmacology
MH  - Flow Cytometry
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Humans
MH  - Interleukin-18/*pharmacology
MH  - MAP Kinase Signaling System/drug effects
MH  - Mitogen-Activated Protein Kinase 1/antagonists & inhibitors
MH  - Mitogen-Activated Protein Kinase 3/antagonists & inhibitors
MH  - RNA Interference
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transferrin/genetics/metabolism/*pharmacology
EDAT- 2009/06/19 09:00
MHDA- 2010/01/08 06:00
CRDT- 2009/06/19 09:00
PHST- 2008/09/30 00:00 [received]
PHST- 2009/05/21 00:00 [revised]
PHST- 2009/05/25 00:00 [accepted]
PHST- 2009/06/19 09:00 [entrez]
PHST- 2009/06/19 09:00 [pubmed]
PHST- 2010/01/08 06:00 [medline]
AID - S0304-3835(09)00380-2 [pii]
AID - 10.1016/j.canlet.2009.05.025 [doi]
PST - ppublish
SO  - Cancer Lett. 2009 Dec 28;286(2):189-95. doi: 10.1016/j.canlet.2009.05.025. Epub 
      2009 Jun 16.