PMID- 19535354
OWN - NLM
STAT- MEDLINE
DCOM- 20091008
LR  - 20171114
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 80
IP  - 10
DP  - 2009 Oct
TI  - The longitudinal profile of CSF markers during external lumbar drainage.
PG  - 1130-3
LID - 10.1136/jnnp.2008.171686 [doi]
AB  - BACKGROUND: External lumbar drainage (ELD) is known as a good predictor of 
      favourable outcome in shunting patients suffering from idiopathic normal pressure 
      hydrocephalus (iNPH). METHODS: Eleven patients suffering from iNPH had a lumbar 
      drain (LD) inserted for 72 h and participated in a research study to quantify any 
      improvement in their clinical symptoms. The lumbar cerebrospinal fluid (CSF) 
      levels of lactate, 8-isoprostane, vascular endothelial growth factor (VEGF), 
      glial fibrillar acidic protein (GFAP), neurofilament (heavy chain) protein (NF 
      (h)), Abeta(1-42) (beta-amyloid) and total tau were assayed samples from all 
      three time points. RESULTS: The concentrations of lactate, VEGF, GFAP and tau 
      increased significantly during the 72 h of drainage. There were also increases in 
      8-isoprostane and Abeta(1-42) (non significant). The concentration of NF (h) was 
      reduced significantly following 72 h of drainage. There was a significant 
      positive correlation between Abeta(1-42) and total tau in the first sample. GFAP 
      was negatively correlated in a significant fashion with both Abeta(1-42) and 
      total tau. NF (h) was negatively correlated with VEGF. CONCLUSION: Evidence is 
      provided that ELD is producing measurable changes in the CSF composition of 
      patients with iNPH. The present paper discusses how such changes may be 
      implicated in the pathophysiology of the condition.
FAU - Tarnaris, A
AU  - Tarnaris A
AD  - Victor Horsley Department of Neurosurgery, National Hospital for Neurology and 
      Neurosurgery, Queen Square, London, UK. andrewtarnaris@gmail.com
FAU - Toma, A K
AU  - Toma AK
FAU - Chapman, M D
AU  - Chapman MD
FAU - Petzold, A
AU  - Petzold A
FAU - Kitchen, N D
AU  - Kitchen ND
FAU - Keir, G
AU  - Keir G
FAU - Watkins, L D
AU  - Watkins LD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090616
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Biomarkers)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Neurofilament Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (amyloid beta-protein (1-42))
RN  - 0 (tau Proteins)
RN  - 27415-26-5 (8-epi-prostaglandin F2alpha)
RN  - 33X04XA5AT (Lactic Acid)
RN  - B7IN85G1HY (Dinoprost)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyloid beta-Peptides/cerebrospinal fluid
MH  - Biomarkers/cerebrospinal fluid
MH  - Dinoprost/analogs & derivatives/cerebrospinal fluid
MH  - *Drainage
MH  - Female
MH  - Glial Fibrillary Acidic Protein/cerebrospinal fluid
MH  - Humans
MH  - Hydrocephalus, Normal Pressure/*cerebrospinal fluid/physiopathology/*therapy
MH  - Lactic Acid/cerebrospinal fluid
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Neurofilament Proteins/cerebrospinal fluid
MH  - Peptide Fragments/cerebrospinal fluid
MH  - Spinal Puncture
MH  - Vascular Endothelial Growth Factor A/cerebrospinal fluid
MH  - tau Proteins/cerebrospinal fluid
EDAT- 2009/06/19 09:00
MHDA- 2009/10/09 06:00
CRDT- 2009/06/19 09:00
PHST- 2009/06/19 09:00 [entrez]
PHST- 2009/06/19 09:00 [pubmed]
PHST- 2009/10/09 06:00 [medline]
AID - jnnp.2008.171686 [pii]
AID - 10.1136/jnnp.2008.171686 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2009 Oct;80(10):1130-3. doi: 
      10.1136/jnnp.2008.171686. Epub 2009 Jun 16.