PMID- 19536361
OWN - NLM
STAT- MEDLINE
DCOM- 20090915
LR  - 20171116
IS  - 0379-0355 (Print)
IS  - 0379-0355 (Linking)
VI  - 31
IP  - 3
DP  - 2009 Apr
TI  - Is referring patients with a positive history of allergic drug reactions or atopy 
      for allergy testing to local anesthetics justified?
PG  - 177-82
LID - 10.1358/mf.2009.31.3.1354126 [doi]
AB  - Although no more than 1% of adverse reactions to local anesthetics (LA) are 
      thought to be immunologically mediated, many patients continue to be referred to 
      allergy clinics for allergy workup. We evaluated the impact of a history of drug 
      hypersensitivity or atopy on results of allergy testing to LA, with the aim of 
      determining the appropriateness of allergy testing to LA in such patients. We 
      retrospectively analyzed medical records of 112 consecutive patients referred for 
      allergy testing to LA in a 9-year period (1996-2005). Intradermal tests with 
      diluted (1:10) LA were performed to identify patients at risk for immunoglobulin 
      E (IgE)-mediated hypersensitivity reaction. The odds for being testpositive were 
      calculated with regard to the defined risk factors (atopy, history of adverse 
      reactions to LA or other drugs, underlying autoimmune disease). Eleven of 112 
      patients (9.8%) tested positive for allergy to LA. Atopy, history of adverse 
      reactions to LA or other drugs and underlying autoimmune disease did not increase 
      the odds for being test-positive. The prevalence of multiple drug 
      hypersensitivity, IgE values and eosinophil count were not significantly higher 
      among the patients who tested positive as compared to the patients who tested 
      negative. According to our data, allergy testing to LA is not justified in 
      patients with atopy or histories of adverse drug reactions other than to LA. 
      Further studies using validated methods of allergy testing to LA coupled with 
      analysis of defined risk factors are needed to definitively establish the 
      indications for referral of patients for allergy testing to LA.
CI  - Copyright 2009 Prous Science, S.A.U. or its licensors. All rights reserved.
FAU - Erdeljic, Viktorija
AU  - Erdeljic V
AD  - Department of Clinical Pharmacology, Department of Medicine, University Hospital 
      Zagreb, Zagreb, Croatia. verdeljic@gmail.com.
FAU - Francetic, Igor
AU  - Francetic I
FAU - Likic, Robert
AU  - Likic R
FAU - Bakran, Ivan
AU  - Bakran I
FAU - Makar-Ausperger, Ksenija
AU  - Makar-Ausperger K
FAU - Simic, Petra
AU  - Simic P
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Methods Find Exp Clin Pharmacol
JT  - Methods and findings in experimental and clinical pharmacology
JID - 7909595
RN  - 0 (Anesthetics, Local)
SB  - IM
MH  - Adult
MH  - Anesthetics, Local/*adverse effects
MH  - Contraindications
MH  - Drug Hypersensitivity/*complications
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*complications
MH  - Intradermal Tests/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Referral and Consultation/*standards
MH  - Risk Factors
EDAT- 2009/06/19 09:00
MHDA- 2009/09/16 06:00
CRDT- 2009/06/19 09:00
PHST- 2009/06/19 09:00 [entrez]
PHST- 2009/06/19 09:00 [pubmed]
PHST- 2009/09/16 06:00 [medline]
AID - 1354126 [pii]
AID - 10.1358/mf.2009.31.3.1354126 [doi]
PST - ppublish
SO  - Methods Find Exp Clin Pharmacol. 2009 Apr;31(3):177-82. doi: 
      10.1358/mf.2009.31.3.1354126.