PMID- 19536817
OWN - NLM
STAT- MEDLINE
DCOM- 20090820
LR  - 20210102
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 125
IP  - 6
DP  - 2009 Sep 15
TI  - Undifferentiated nasopharyngeal carcinoma from a nonendemic area: protective role 
      of HLA allele products presenting conserved EBV epitopes.
PG  - 1358-64
LID - 10.1002/ijc.24515 [doi]
AB  - The role of genetic factors involved in the development of undifferentiated 
      nasopharyngeal carcinoma (UNPC) in nonendemic areas has been poorly investigated. 
      High-resolution human leukocyte antigen (HLA) class I genotyping carried out in 
      82 Italian UNPC patients and 286 bone marrow donors born in the same province 
      showed that A*0201, B*1801, and B*3501, known to efficiently present Epstein-Barr 
      virus (EBV)-derived epitopes, were significantly under-represented in UNPC 
      patients. Moreover, the A*0201/B*1801 haplotype was significantly less frequent 
      in UNPC cases, with a 90% reduced risk (odds ratio [OR] 0.1, 95% confidence 
      interval [CI] = 0.0-0.5) to develop UNPC, suggesting an additive effect. Notably, 
      all 5 BARF1 epitopes and 7 of the 8 LMP-2 epitopes known to bind A*0201 showed a 
      fully conserved sequence in all the 31 Italian EBV isolates investigated. The 4 
      amino acid changes affecting the 436-447 LMP-2 epitope do not reduce, but rather 
      increase in two cases, the predicted ability of "variant" epitopes to bind the 
      HLA-A*0201 allele, as shown by immunoinformatic analysis. Moreover, a 
      significantly increased risk for UNPC was associated with A*2601 (OR 2.4, 95% CI 
      = 1.1-4.9) and B*4101 (OR 9.2, 95% CI = 2.5-34.3). These findings indicate that 
      Italian UNPC patients have a distinct HLA-A and -B genotypic profile and suggest 
      that the decreased risk for UNPC conferred by definite HLA class I molecules is 
      probably related to their ability to efficiently present LMP-2 and BARF1 epitopes 
      that are highly conserved in EBV isolates from this geographic region. These 
      results have practical implications for the immunotherapy of UNPC.
CI  - 2009 UICC
FAU - Pasini, Elisa
AU  - Pasini E
AD  - Cancer Bioimmunotherapy Unit, IRCCS-National Cancer Institute, Aviano (PN), 
      Italy.
FAU - Caggiari, Laura
AU  - Caggiari L
FAU - Dal Maso, Luigino
AU  - Dal Maso L
FAU - Martorelli, Debora
AU  - Martorelli D
FAU - Guidoboni, Massimo
AU  - Guidoboni M
FAU - Vaccher, Emanuela
AU  - Vaccher E
FAU - Barzan, Luigi
AU  - Barzan L
FAU - Franchin, Giovanni
AU  - Franchin G
FAU - Gloghini, Annunziata
AU  - Gloghini A
FAU - De Re, Valli
AU  - De Re V
FAU - Sacchi, Nicoletta
AU  - Sacchi N
FAU - Serraino, Diego
AU  - Serraino D
FAU - Carbone, Antonino
AU  - Carbone A
FAU - Rosato, Antonio
AU  - Rosato A
FAU - Dolcetti, Riccardo
AU  - Dolcetti R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (BARF1 protein, Human herpesvirus 4)
RN  - 0 (EBV-associated membrane antigen, Epstein-Barr virus)
RN  - 0 (Epitopes)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Viral Matrix Proteins)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Cell Differentiation
MH  - Epitopes/*immunology
MH  - Epstein-Barr Virus Infections/*genetics/immunology/virology
MH  - Female
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Herpesvirus 4, Human/physiology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lymphocytes/immunology
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/*genetics/virology
MH  - Viral Matrix Proteins/*immunology
MH  - Viral Proteins/*immunology
MH  - Young Adult
EDAT- 2009/06/19 09:00
MHDA- 2009/08/21 09:00
CRDT- 2009/06/19 09:00
PHST- 2009/06/19 09:00 [entrez]
PHST- 2009/06/19 09:00 [pubmed]
PHST- 2009/08/21 09:00 [medline]
AID - 10.1002/ijc.24515 [doi]
PST - ppublish
SO  - Int J Cancer. 2009 Sep 15;125(6):1358-64. doi: 10.1002/ijc.24515.