PMID- 19536826
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20131121
IS  - 1552-4965 (Electronic)
IS  - 1549-3296 (Linking)
VI  - 93
IP  - 1
DP  - 2010 Apr
TI  - Nanostructuration of titania films prepared by self-assembly to affect cell 
      adhesion.
PG  - 96-106
LID - 10.1002/jbm.a.32477 [doi]
AB  - Nanostructured and dense titania films prepared by evaporation-induced 
      self-assembly (EISA) are shown to possess tunable topographical nanoscale 
      features on the order 2-12 nm. Thermal treatment (calcination) induces a 
      transition from amorphous titania to crystalline anatase that modifies the 
      chemical and structural properties of the surfaces via the migration of matter. 
      For nanostructured films, the nanoporous network changes from organized 
      ellipsoidal pores, approximately 4 nm x 2 nm, to a grid-like structure with pores 
      on the order of 12 nm, whereas dense films show a slight roughening of the 
      surface. Cells seeded on templated films show measurable, statistically 
      significant differences in morphology compared with cells seeded on dense films. 
      Moreover, although crystallization of templated films results in surfaces that 
      promote less well-spread cells with higher circularities, the opposite trend is 
      observed for dense films. As such, these results represent a new method to tailor 
      interfaces for biomaterial applications, using EISA to control material 
      patterning on the nanoscale. This self-assembly based approach allows the 
      patterning on size scales that are inaccessible by most traditional techniques 
      while offering the added potential to package and control the release of 
      bioactive molecules.
FAU - Bass, John D
AU  - Bass JD
AD  - Laboratoire de Chimie de la Matiere Condensee, Universite Pierre et Marie Curie , 
      UMR 7574 CNRS, 75252 Paris Cedex 05, France.
FAU - Belamie, Emmanuel
AU  - Belamie E
FAU - Grosso, David
AU  - Grosso D
FAU - Boissiere, Cedric
AU  - Boissiere C
FAU - Coradin, Thibaud
AU  - Coradin T
FAU - Sanchez, Clement
AU  - Sanchez C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Mater Res A
JT  - Journal of biomedical materials research. Part A
JID - 101234237
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Animals
MH  - Cell Adhesion/drug effects
MH  - Fibroblasts/*cytology/drug effects
MH  - Hot Temperature
MH  - *Materials Testing
MH  - Mice
MH  - Microscopy, Atomic Force
MH  - Microscopy, Electron, Transmission
MH  - Microscopy, Fluorescence
MH  - NIH 3T3 Cells
MH  - Nanostructures/*chemistry
MH  - Partial Pressure
MH  - Porosity/drug effects
MH  - Surface Properties/drug effects
MH  - Titanium/*chemistry/*pharmacology
MH  - X-Ray Diffraction
EDAT- 2009/06/19 09:00
MHDA- 2010/05/19 06:00
CRDT- 2009/06/19 09:00
PHST- 2009/06/19 09:00 [entrez]
PHST- 2009/06/19 09:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - 10.1002/jbm.a.32477 [doi]
PST - ppublish
SO  - J Biomed Mater Res A. 2010 Apr;93(1):96-106. doi: 10.1002/jbm.a.32477.