PMID- 1953693
OWN - NLM
STAT- MEDLINE
DCOM- 19911212
LR  - 20071115
IS  - 0232-766X (Print)
IS  - 0232-766X (Linking)
VI  - 50
IP  - 3
DP  - 1991
TI  - Intracerebroventricular administration of hypertonic sodium chloride solution 
      reduces the sensitivity of the baroreceptor heart reflex in anaesthetized rats.
PG  - 273-7
AB  - Intracerebroventricular (i.c.v.) infusion of hypertonic sodium chloride solution 
      increased blood pressure (BP) and shortened heart period (interbeat-interval: 
      IBI) that is why an impairment in baroreflex regulation is believed to be part of 
      that process. Therefore, in anaesthetized rats (1.35 g urethane/kg BW) the 
      baroreceptor-heart reflex (BHR) was tested before and during i.c.v. infusion (15 
      min) of isotonic or hypertonic (0.6 M, 1.0 M) sodium chloride solution by 
      inducing an acute BP rise by i.v. pressoric agents (phenylephrine, methoxamine). 
      The evoked reflex prolongation of the IBI was taken to estimate the sensitivity 
      of that BHR (delta ms/mm Hg). Whilst i.c.v. infusion of isotonic sodium chloride 
      solution did not affect BHR sensitivity, hypertonic sodium chloride solution not 
      only elevated BP and shortened IBI but also reset and impaired the BHR. 
      Therefore, an increased central sensitivity to sodium chloride might not only 
      increase BP but also impair the buffering capacity of the BHR against this rise 
      and in this way support development of hypertension.
FAU - Brattstrom, A Jr
AU  - Brattstrom A Jr
AD  - Institute of Physiology, Medical School, Magdeburg, FRG.
FAU - Appenrodt, E
AU  - Appenrodt E
FAU - Brattstrom, A
AU  - Brattstrom A
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Biomed Biochim Acta
JT  - Biomedica biochimica acta
JID - 8304435
RN  - 0 (Saline Solution, Hypertonic)
SB  - IM
MH  - Anesthesia
MH  - Animals
MH  - Blood Pressure/*drug effects/physiology
MH  - Heart Rate/*drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Pressoreceptors/*drug effects/physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Saline Solution, Hypertonic/*administration & dosage/pharmacology
MH  - Statistics as Topic
EDAT- 1991/01/11 19:15
MHDA- 2001/03/28 10:01
CRDT- 1991/01/11 19:15
PHST- 1991/01/11 19:15 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1991/01/11 19:15 [entrez]
PST - ppublish
SO  - Biomed Biochim Acta. 1991;50(3):273-7.