PMID- 19537302
OWN - NLM
STAT- MEDLINE
DCOM- 20090923
LR  - 20191111
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 23
IP  - 3
DP  - 2009 Jun-Jul
TI  - Incidence of pancreas graft thrombosis using low-molecular-weight heparin.
PG  - 407-14
AB  - INTRODUCTION: Simultaneous pancreas-kidney transplantation is the current 
      treatment of choice for patients with type I diabetes and end stage renal 
      disease. Vascular graft thrombosis (VGT) after pancreas transplantation is the 
      main cause of early graft loss. METHODS: A total of 188 consecutive pancreas 
      transplantations were performed between January 2000 and December 2006. A 
      retrospective study was carried out in order to compare incidence of VGT and 
      relaparotomy-for-bleeding rate of once daily fixed dose 
      low-molecular-weight-heparin (LMWH) to dose-adjusted intravenous unfractionated 
      heparin (UFH). RESULTS: Fifty-eight patients receiving LMWH and 129 receiving UFH 
      were identified. There were 7% (4/58) VGTs in the LMWH and 17% (22/129) in the 
      UFH group (p = 0.047). The frequency of major bleeding requiring relaparatomy was 
      not significantly different in the groups related to LMWH and UFH, respectively 
      (6.9% vs. 7.8%). One yr patient and pancreas graft survival was 98.9/89.6% in the 
      LMWH and 97.8/74.4% in the UFH group. Donor and recipient characteristics were 
      similar. CONCLUSION: In our experience once daily fixed dose LMWH might not be 
      inferior to dose-adjusted intravenous heparin in preventing pancreas graft 
      thrombosis.
FAU - Schenker, Peter
AU  - Schenker P
AD  - Department of Surgery, Knappschafts-Hospital, Ruhr-University Bochum, Germany. 
      Peter.Schenker@rub.de
FAU - Vonend, Oliver
AU  - Vonend O
FAU - Ertas, Neslihan
AU  - Ertas N
FAU - Wunsch, Andreas
AU  - Wunsch A
FAU - Schaeffer, Michael
AU  - Schaeffer M
FAU - Rump, Lars-Christian
AU  - Rump LC
FAU - Viebahn, Richard
AU  - Viebahn R
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Anticoagulants/*administration & dosage/adverse effects
MH  - Female
MH  - Heparin/adverse effects
MH  - Heparin, Low-Molecular-Weight/*administration & dosage
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Kaplan-Meier Estimate
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Pancreas Transplantation/*adverse effects
MH  - Postoperative Care
MH  - Retrospective Studies
MH  - Thrombosis/*prevention & control
EDAT- 2009/06/20 09:00
MHDA- 2009/09/24 06:00
CRDT- 2009/06/20 09:00
PHST- 2009/06/20 09:00 [entrez]
PHST- 2009/06/20 09:00 [pubmed]
PHST- 2009/09/24 06:00 [medline]
AID - 10.1111/j.1399-0012.2008.00911.x [doi]
PST - ppublish
SO  - Clin Transplant. 2009 Jun-Jul;23(3):407-14. doi: 
      10.1111/j.1399-0012.2008.00911.x.