PMID- 19538209
OWN - NLM
STAT- MEDLINE
DCOM- 20100105
LR  - 20151113
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 16
IP  - 11
DP  - 2009 Nov
TI  - BDNF Val66Met polymorphism is associated with cognitive impairment in Italian 
      patients with Parkinson's disease.
PG  - 1240-5
LID - 10.1111/j.1468-1331.2009.02706.x [doi]
AB  - BACKGROUND AND PURPOSE: A possible association between Parkinson's disease (PD) 
      and the polymorphism of Brain Derived Neurotrophic Factor (BDNF) G196A (Val66Met) 
      has been suggested by different studies that nevertheless yielded-contrasting 
      result. The purpose of this study was to analyze such possible association in a 
      cohort of Italian PD patients. METHODS: The BDNF polymorphisms were analyzed in 
      294 Italian patients with PD; results were compared to those obtained in 233 age- 
      and sex-matched healthy controls (HC) enrolled from two tertiary centres in 
      Italy. Polymorphisms were determined by Restriction Fragment Length Polymorphism 
      (RFLP) analysis; correlations between BDNF G196A polymorphism, and cognitive 
      function were established by sub analyzing the results upon dividing PD patients 
      based on their Mini Mental State Examination (MMSE) score. RESULTS: Univariate 
      analysis showed a highly significant correlation between the BDNF(AA) genotype 
      and a MMSE score < or =24. Hence, the distribution of this genotype in PD 
      individuals with a MMSE score < or =24 was significantly increased compared to PD 
      patients with an MMSE score >24 and HC (P < 0.001 in both cases). Multivariate 
      analyses showed that BDNF (AA) genotype was associated to a sixfold risk of 
      cognitive impairment. CONCLUSIONS: The BDNF(AA) homozygote genotype is 
      over-represented in PD patients compared with normal individuals; this genotype 
      was significantly correlated to cognitive impairment, age and disease severity. 
      These results, although preliminary, could be important in establishing novel 
      diagnostic and therapeutic approaches to PD.
FAU - Guerini, F R
AU  - Guerini FR
AD  - Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation 
      IRCCS, Milan, Italy. fguerini@dongnocchi.it
FAU - Beghi, E
AU  - Beghi E
FAU - Riboldazzi, G
AU  - Riboldazzi G
FAU - Zangaglia, R
AU  - Zangaglia R
FAU - Pianezzola, C
AU  - Pianezzola C
FAU - Bono, G
AU  - Bono G
FAU - Casali, C
AU  - Casali C
FAU - Di Lorenzo, C
AU  - Di Lorenzo C
FAU - Agliardi, C
AU  - Agliardi C
FAU - Nappi, G
AU  - Nappi G
FAU - Clerici, M
AU  - Clerici M
FAU - Martignoni, E
AU  - Martignoni E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090615
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Chi-Square Distribution
MH  - Cognition Disorders/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Parkinson Disease/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Regression Analysis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Severity of Illness Index
EDAT- 2009/06/23 09:00
MHDA- 2010/01/06 06:00
CRDT- 2009/06/23 09:00
PHST- 2009/06/23 09:00 [entrez]
PHST- 2009/06/23 09:00 [pubmed]
PHST- 2010/01/06 06:00 [medline]
AID - ENE2706 [pii]
AID - 10.1111/j.1468-1331.2009.02706.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2009 Nov;16(11):1240-5. doi: 10.1111/j.1468-1331.2009.02706.x. Epub 
      2009 Jun 15.