PMID- 1953916
OWN - NLM
STAT- MEDLINE
DCOM- 19911230
LR  - 20051116
IS  - 0904-1850 (Print)
IS  - 0904-1850 (Linking)
VI  - 13
DP  - 1991 Apr
TI  - Bronchoalveolar lavage and lymphocytes in asthma.
PG  - 39s-46s
AB  - Asthma is characterized by airway inflammation and hyperreactivity. The purpose 
      of this review is firstly to look at the current status of bronchoalveolar lavage 
      (BAL) as a tool for asthma research, and secondly to focus on the role that the 
      lymphocyte plays in the inflammatory component of asthma. BAL is now widely 
      accepted as a productive means of investigating asthma and it can be carried out 
      safely on stable, mild asthmatics. Its safety in the face of moderate to severe 
      disease has yet to be established. Lymphocytes play a pivotal role in modulating 
      the immune response both in normal conditions and in the inflammatory response 
      which characterizes the asthmatic airway. Lymphocytes control key steps in the 
      asthmatic response by producing immunoglobulin E (IgE) and other antibodies, 
      regulating effector cells such as eosinophils and mast cells, and by influencing 
      the host-response to upper respiratory tract viral infections. Asthmatic patients 
      may have a defect in their suppressor T cell system.
FAU - Crump, J W
AU  - Crump JW
AD  - Dept of Medicine, Veterans Affairs Medical Center, Iowa City, Iowa.
FAU - Pueringer, R J
AU  - Pueringer RJ
FAU - Hunninghake, G W
AU  - Hunninghake GW
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur Respir J Suppl
JT  - The European respiratory journal. Supplement
JID - 8910681
SB  - IM
MH  - Asthma/etiology/*immunology
MH  - *Bronchoalveolar Lavage Fluid/cytology
MH  - Eosinophils/immunology
MH  - Humans
MH  - Lymphocytes/*immunology
MH  - Mast Cells/immunology
MH  - Respiratory System/immunology
RF  - 93
EDAT- 1991/04/01 00:00
MHDA- 1991/04/01 00:01
CRDT- 1991/04/01 00:00
PHST- 1991/04/01 00:00 [pubmed]
PHST- 1991/04/01 00:01 [medline]
PHST- 1991/04/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J Suppl. 1991 Apr;13:39s-46s.