PMID- 1953921
OWN - NLM
STAT- MEDLINE
DCOM- 19911230
LR  - 20061115
IS  - 0904-1850 (Print)
IS  - 0904-1850 (Linking)
VI  - 13
DP  - 1991 Apr
TI  - The IgE response and atopy.
PG  - 78s-84s
AB  - The relationship between atopy and immunoglobulin E (IgE) is discussed. The 
      following conclusions/hypotheses are reached: 1. IgE is typical of, but not 
      unique for atopy. 2. IgE is specific for atopy under conditions of marginal 
      antigen presentation. 3. Under normal antigen stimulation conditions, i.e. 
      conditions which lead to the formation of antibodies but not usually to that of 
      IgE antibodies, the IgE-route of B-cell activation/differentiation is blocked, 
      perhaps by interference with the biological activity of CD23 by IgE. 4. Under 
      "strong" antigen stimulation the IgE blockade is circumvented, presumably via the 
      production of excessive amounts of interleukin-4 (IL-4). 5. Cross-reactive 
      priming in the gut might enhance the induction of IgE antibodies to inhalant 
      allergens, according to the principle "IgE breeds IgE".
FAU - Aalberse, R C
AU  - Aalberse RC
AD  - Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, 
      Amsterdam.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Eur Respir J Suppl
JT  - The European respiratory journal. Supplement
JID - 8910681
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibody Specificity
MH  - B-Lymphocytes/immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/*immunology
MH  - Immunoglobulin E/*immunology
MH  - Immunoglobulin G/immunology
MH  - Lymphocyte Activation
RF  - 22
EDAT- 1991/04/01 00:00
MHDA- 1991/04/01 00:01
CRDT- 1991/04/01 00:00
PHST- 1991/04/01 00:00 [pubmed]
PHST- 1991/04/01 00:01 [medline]
PHST- 1991/04/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J Suppl. 1991 Apr;13:78s-84s.