PMID- 19539752
OWN - NLM
STAT- MEDLINE
DCOM- 20091203
LR  - 20240312
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 31
IP  - 5
DP  - 2009 Sep-Oct
TI  - Simultaneous prenatal ethanol and nicotine exposure affect ethanol consumption, 
      ethanol preference and oxytocin receptor binding in adolescent and adult rats.
PG  - 291-302
LID - 10.1016/j.ntt.2009.06.001 [doi]
AB  - Ethanol consumption and smoking during pregnancy are common, despite the known 
      adverse effects on the fetus. The teratogenicity of each drug independently is 
      well established; however, the effects of concurrent exposure to ethanol and 
      nicotine in preclinical models remain unclear. This study examined the impact of 
      simultaneous prenatal exposure to both ethanol and nicotine on offspring ethanol 
      preference behaviors and oxytocin system dynamics. Rat dams were given liquid 
      diet (17% ethanol derived calories (EDC)) on gestational day (GD) 5 and 35% EDC 
      from GD 6-20 and concurrently an osmotic minipump delivered nicotine 
      (3-6mg/kg/day) from GD 4-postpartum day 10. Offspring were tested for ethanol 
      preference during adolescence (postnatal day (PND) 30-43) and again at adulthood 
      (PND 60-73), followed by assays for oxytocin mRNA expression and receptor binding 
      in relevant brain regions. Prenatal exposure decreased ethanol preference in 
      males during adolescence, and decreased consumption and preference in females 
      during adulthood compared to controls. Oxytocin receptor binding in the nucleus 
      accumbens and hippocampus was increased in adult prenatally exposed males only. 
      Prenatal exposure to these drugs sex-specifically decreased ethanol preference 
      behavior in offspring unlike reports for either drug separately. The possible 
      role of oxytocin in reduction of ethanol consumption behavior is highlighted.
FAU - Williams, Sarah K
AU  - Williams SK
AD  - Curriculum in Neurobiology, The University of North Carolina at Chapel Hill, 
      Chapel Hill, NC 27599, USA. sarahk_williams@med.unc.edu
FAU - Cox, Elizabeth T
AU  - Cox ET
FAU - McMurray, Matthew S
AU  - McMurray MS
FAU - Fay, Emily E
AU  - Fay EE
FAU - Jarrett, Thomas M
AU  - Jarrett TM
FAU - Walker, Cheryl H
AU  - Walker CH
FAU - Overstreet, David H
AU  - Overstreet DH
FAU - Johns, Josephine M
AU  - Johns JM
LA  - eng
GR  - R01 DA013283-05/DA/NIDA NIH HHS/United States
GR  - P60 AA011605/AA/NIAAA NIH HHS/United States
GR  - P50 AA011605/AA/NIAAA NIH HHS/United States
GR  - R01 DA013362/DA/NIDA NIH HHS/United States
GR  - R01-DA13283/DA/NIDA NIH HHS/United States
GR  - R01 DA013283/DA/NIDA NIH HHS/United States
GR  - R01 DA013362-01/DA/NIDA NIH HHS/United States
GR  - P60 AA011605-10/AA/NIAAA NIH HHS/United States
GR  - R29 DA008456-05/DA/NIDA NIH HHS/United States
GR  - AA11605-10/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090617
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Receptors, Oxytocin)
RN  - 3K9958V90M (Ethanol)
RN  - 50-56-6 (Oxytocin)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - *Alcohol Drinking
MH  - Animals
MH  - Choice Behavior/*drug effects
MH  - Drug Interactions
MH  - Ethanol/*toxicity
MH  - Female
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Nicotine/*toxicity
MH  - Nucleus Accumbens/drug effects/metabolism
MH  - Oxytocin/metabolism
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Oxytocin/*metabolism
MH  - Sex Characteristics
PMC - PMC2743885
MID - NIHMS125020
EDAT- 2009/06/23 09:00
MHDA- 2009/12/16 06:00
PMCR- 2010/09/01
CRDT- 2009/06/23 09:00
PHST- 2009/02/06 00:00 [received]
PHST- 2009/05/21 00:00 [revised]
PHST- 2009/06/09 00:00 [accepted]
PHST- 2009/06/23 09:00 [entrez]
PHST- 2009/06/23 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - S0892-0362(09)00134-2 [pii]
AID - 10.1016/j.ntt.2009.06.001 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2009 Sep-Oct;31(5):291-302. doi: 10.1016/j.ntt.2009.06.001. 
      Epub 2009 Jun 17.