PMID- 19540194
OWN - NLM
STAT- MEDLINE
DCOM- 20090814
LR  - 20131121
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 387
IP  - 1
DP  - 2009 Sep 11
TI  - Intake of dissolved organic matter from deep seawater inhibits atherosclerosis 
      progression.
PG  - 25-30
LID - 10.1016/j.bbrc.2009.06.073 [doi]
AB  - Dissolved organic matter (DOM) in seawater can be defined as the fraction of 
      organic matter that passes through a filter of sub micron pore size. In this 
      study, we have examined the effect of DOM of deep seawater (DSW) from Pacific 
      Ocean on platelet aggregation and atherosclerosis progression. DSW was passed 
      through a series of filters and then through an Octadecyl C18 filter; the 
      retained substance in ethanol was designated as C18 extractable DOM (C18-DOM). 
      Our studies showed that C18-DOM treatment inhibited platelet aggregation, 
      P-selectin expression and activity of COX-1 significantly. C18-DOM increased the 
      expression of anti-atherogenic molecule namely heme oxygenase-1 in endothelial 
      cells and all these data showed that C18-DOM is exhibiting aspirin-like effects. 
      Moreover our in vivo studies showed that C18-DOM feeding slowed remarkably the 
      progression of atherosclerosis. Our study demonstrated a novel biological effect 
      of oceanic DOM, which has several important implications, including a possible 
      therapeutic strategy for atherosclerosis.
FAU - Radhakrishnan, Geethalakshmi
AU  - Radhakrishnan G
AD  - Department of Surgery II, Faculty of Medicine, Kochi University, Japan.
FAU - Yamamoto, Morio
AU  - Yamamoto M
FAU - Maeda, Hironori
AU  - Maeda H
FAU - Nakagawa, Aimi
AU  - Nakagawa A
FAU - KatareGopalrao, Rajesh
AU  - KatareGopalrao R
FAU - Okada, Hironobu
AU  - Okada H
FAU - Nishimori, Hideaki
AU  - Nishimori H
FAU - Wariishi, Seiichiro
AU  - Wariishi S
FAU - Toda, Eiji
AU  - Toda E
FAU - Ogawa, Hiroshi
AU  - Ogawa H
FAU - Sasaguri, Shiro
AU  - Sasaguri S
LA  - eng
PT  - Journal Article
DEP - 20090618
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Enzymes, Immobilized)
RN  - 0 (P-Selectin)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.14.99.1 (Cyclooxygenase 1)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*chemistry/pharmacology
MH  - Aspirin/pharmacology
MH  - Atherosclerosis/drug therapy/*metabolism
MH  - Biosensing Techniques
MH  - Cholesterol/metabolism
MH  - Cyclooxygenase 1/chemistry/drug effects
MH  - Cyclooxygenase Inhibitors/*chemistry/pharmacology
MH  - Enzymes, Immobilized/antagonists & inhibitors/chemistry
MH  - P-Selectin/antagonists & inhibitors
MH  - Platelet Aggregation/drug effects
MH  - Rabbits
MH  - Seawater/*chemistry
MH  - Tunica Intima/drug effects/metabolism
EDAT- 2009/06/23 09:00
MHDA- 2009/08/15 09:00
CRDT- 2009/06/23 09:00
PHST- 2009/06/09 00:00 [received]
PHST- 2009/06/13 00:00 [accepted]
PHST- 2009/06/23 09:00 [entrez]
PHST- 2009/06/23 09:00 [pubmed]
PHST- 2009/08/15 09:00 [medline]
AID - S0006-291X(09)01227-3 [pii]
AID - 10.1016/j.bbrc.2009.06.073 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2009 Sep 11;387(1):25-30. doi: 
      10.1016/j.bbrc.2009.06.073. Epub 2009 Jun 18.