PMID- 19541884
OWN - NLM
STAT- MEDLINE
DCOM- 20090917
LR  - 20090622
IS  - 0956-4624 (Print)
IS  - 0956-4624 (Linking)
VI  - 20
IP  - 7
DP  - 2009 Jul
TI  - A brief review of potential mechanisms of immune reconstitution inflammatory 
      syndrome in HIV following antiretroviral therapy.
PG  - 447-52
LID - 10.1258/ijsa.2009.008521 [doi]
AB  - A subset of HIV-infected individuals who receive antiretroviral therapy (ART) 
      develop a paradoxical pathological response that significantly increases 
      morbidity and sometimes mortality. Following the induction of highly active ART, 
      a rapid decline in the viral load results within weeks and coincides with a steep 
      rise in the CD4(+) T-cell counts and immune hyperactivation. Although no 
      mechanistic pathway has been elucidated for the development of immune 
      reconstitution inflammatory syndrome (IRIS), it is thought that change in the 
      nature of the immune response is a predominant factor in the development of 
      reconstitution disease. In this article, we review the current state of knowledge 
      in this field and provide a model for the development of IRIS.
FAU - Mori, S
AU  - Mori S
AD  - The University of Texas Health Sciences Center, Houston, Internal Medicine 
      Program, Houston, Texas, USA. shahram.mori@uth.tmc.edu
FAU - Levin, P
AU  - Levin P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
SB  - IM
MH  - *Antiretroviral Therapy, Highly Active
MH  - HIV Infections/*complications/*drug therapy/immunology
MH  - HIV-1
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*etiology/immunology
MH  - Risk Factors
RF  - 58
EDAT- 2009/06/23 09:00
MHDA- 2009/09/18 06:00
CRDT- 2009/06/23 09:00
PHST- 2009/06/23 09:00 [entrez]
PHST- 2009/06/23 09:00 [pubmed]
PHST- 2009/09/18 06:00 [medline]
AID - 20/7/447 [pii]
AID - 10.1258/ijsa.2009.008521 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2009 Jul;20(7):447-52. doi: 10.1258/ijsa.2009.008521.