PMID- 19542613
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20211020
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 17
IP  - 4
DP  - 2009
TI  - BDNF variants, premorbid educational attainment, and disease characteristics in 
      Alzheimer's disease: an exploratory study.
PG  - 887-98
LID - 10.3233/JAD-2009-1106 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a neurotrophin that promotes neuronal 
      survival, growth, and differentiation. The role of BDNF in learning and memory 
      suggests that it may also modulate the clinical course of Alzheimer's disease 
      (AD). This study aimed to determine whether BDNF genetic variants are related to 
      premorbid educational attainment, progression of cognitive and functional 
      decline, and associated neuropsychiatric symptoms in AD patients. A sample of AD 
      subjects (N = 341) was genotyped for the BDNF polymorphisms: Val66Met, C270T, and 
      G-712A. Subjects received tests of cognition and daily function at baseline and 
      at multiple subsequent time points. They were also characterized for the 
      frequency and severity of neuropsychiatric symptoms. There was a significant 
      effect of Val66Met genotype on educational attainment (F = 7.49, df = 2,329, P = 
      0.00066), with Met/Met homozygotes having significantly lower education than both 
      the Val/Met and Val/Val groups. No association was observed between any BDNF 
      polymorphism and measures of cognitive or functional decline. The T-allele of the 
      C270T polymorphism was associated with a higher prevalence of neuropsychiatric 
      symptoms and specifically with the presence of hallucinations. The effect of the 
      Val66Met polymorphism on premorbid educational attainment is intriguing and 
      should be verified in a larger sample.
FAU - Zdanys, Kristina F
AU  - Zdanys KF
AD  - Alzheimer's Disease Research Unit, Department of Psychiatry, Yale University 
      School of Medicine, New Haven, CT 06510, USA.
FAU - Kleiman, Timothy G
AU  - Kleiman TG
FAU - Zhang, Huiping
AU  - Zhang H
FAU - Ozbay, Fatih
AU  - Ozbay F
FAU - MacAvoy, Martha G
AU  - MacAvoy MG
FAU - Gelernter, Joel
AU  - Gelernter J
FAU - van Dyck, Christopher H
AU  - van Dyck CH
LA  - eng
GR  - K24 DA015105/DA/NIDA NIH HHS/United States
GR  - K24-DA15105/DA/NIDA NIH HHS/United States
GR  - P30-MH30929/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Alzheimer Disease/*genetics/physiopathology/psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - *Cognition
MH  - Disease Progression
MH  - Educational Status
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Hallucinations/epidemiology/*genetics
MH  - Humans
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Prevalence
MH  - Retrospective Studies
MH  - Severity of Illness Index
PMC - PMC4084650
MID - NIHMS582140
EDAT- 2009/06/23 09:00
MHDA- 2010/09/24 06:00
PMCR- 2014/07/07
CRDT- 2009/06/23 09:00
PHST- 2009/06/23 09:00 [entrez]
PHST- 2009/06/23 09:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
PHST- 2014/07/07 00:00 [pmc-release]
AID - 8785121042221767 [pii]
AID - 10.3233/JAD-2009-1106 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2009;17(4):887-98. doi: 10.3233/JAD-2009-1106.