PMID- 19543212
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20111117
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 17
IP  - 10
DP  - 2009 Oct
TI  - Effect of a high-fat diet on 24-hour pattern of circulating adipocytokines in 
      rats.
PG  - 1866-71
LID - 10.1038/oby.2009.200 [doi]
AB  - We have shown a significant disruption of 24-h pattern of plasma pituitary, 
      adrenal, and gonadal hormones in high-fat-fed rats. Our objective was to assess 
      the effect of a high-fat diet (35% fat) on mean levels and 24-h pattern of 
      several adipocytokines in rats. A normal diet-fed rats (4% fat) were used as 
      controls. When body weight of high-fat-fed rats attained values about 25% higher 
      than controls (after 66 days of treatment), the animals were killed at six 
      different time intervals throughout a 24-h cycle. Plasma concentrations of 
      insulin, adiponectin, interleukin (IL)-1, leptin, ghrelin, plasminogen activator 
      inhibitor-1 (PAI-1), and monocyte chemoattractant protein-1 (MCP-1) were measured 
      in a multianalyte profiling by using the Luminex-100 system. Tumor necrosis 
      factor alpha (TNFalpha) and IL-6 were measured by enzyme-linked immunosorbent 
      assay. A significant hyperglycemia developed in high-fat-fed rats, together with 
      a significant increase in plasma insulin. Mean levels of plasma adiponectin, 
      IL-1, IL-6, TNFalpha, and leptin augmented, and ghrelin decreased, in 
      high-fat-fed rats. The normal daily pattern of plasma insulin, adiponectin, IL-1, 
      IL-6, TNFalpha, leptin, ghrelin, and MCP-1 became disrupted in high-fat-fed rats. 
      The results indicate that a high-fat diet may bring about signs of insulin 
      resistance and mild inflammation in rats, together with the disruption in daily 
      variations of circulating insulin and ghrelin, and of several adipocytokines 
      including leptin, adiponectin, IL-1, IL-6, TNFalpha, and MCP-1.
FAU - Cano, Pilar
AU  - Cano P
AD  - Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, 
      Universidad Complutense, Madrid, Spain.
FAU - Cardinali, Daniel P
AU  - Cardinali DP
FAU - Rios-Lugo, Maria J
AU  - Rios-Lugo MJ
FAU - Fernandez-Mateos, Maria P
AU  - Fernandez-Mateos MP
FAU - Reyes Toso, Carlos F
AU  - Reyes Toso CF
FAU - Esquifino, Ana I
AU  - Esquifino AI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090618
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Blood Glucose)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Ghrelin)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adipokines/*blood
MH  - Adiponectin/blood
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Chemokine CCL2/blood
MH  - Circadian Rhythm/*physiology
MH  - Ghrelin/blood
MH  - Insulin/blood
MH  - Interleukin-1/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Obesity/*blood/metabolism
MH  - Plasminogen Activator Inhibitor 1/blood
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2009/06/23 09:00
MHDA- 2010/01/27 06:00
CRDT- 2009/06/23 09:00
PHST- 2009/06/23 09:00 [entrez]
PHST- 2009/06/23 09:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - oby2009200 [pii]
AID - 10.1038/oby.2009.200 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2009 Oct;17(10):1866-71. doi: 10.1038/oby.2009.200. Epub 
      2009 Jun 18.