PMID- 19543247
OWN - NLM
STAT- MEDLINE
DCOM- 20091110
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Linking)
VI  - 22
IP  - 9
DP  - 2009 Sep
TI  - Chromosomal copy number changes supporting the classification of lentiginous 
      junctional melanoma of the elderly as a subtype of melanoma.
PG  - 1258-62
LID - 10.1038/modpathol.2009.93 [doi]
AB  - Recently the term lentiginous melanoma of the elderly has been suggested for a 
      pattern of melanocytic neoplasia characterized by frequent occurrence in elderly 
      patients, broad lentiginous growth pattern, with poorly cohesive nesting, 
      suprabasilar extension of melanocytes and moderate cytological atypia. However, 
      there are limited reported cases with follow-up information to confirm the 
      malignant nature of these neoplasms. Using fluorescence in situ hybridization 
      (FISH) targeting chromosomal loci that are frequently found to have copy number 
      changes in melanoma, we evaluated cases of lentiginous junctional melanoma of the 
      elderly in order to compare with the frequencies and patterns of chromosomal 
      aberrations identified in other subtypes of melanoma. Previous studies have shown 
      that by using a FISH assay targeting 6p25, 6q23, 11q13 and CEP6 with previously 
      validated criteria, one could discriminate benign nevi from melanoma with high 
      sensitivity and specificity. In this study, 16 of 19 cases (84%) showed 
      sufficient copy number changes in one of the targeted chromosomal loci to meet 
      FISH criteria for melanoma. A total of 17 control cases of lentiginous junctional 
      nevi tested negative for all criteria. These findings support the classification 
      of this pattern of melanocytic neoplasia as a subtype of melanoma.
FAU - Newman, Marissa D
AU  - Newman MD
AD  - Department of Dermatology, The Feinberg School of Medicine, Northwestern 
      University, Chicago, IL 60611, USA.
FAU - Mirzabeigi, Marjan
AU  - Mirzabeigi M
FAU - Gerami, Pedram
AU  - Gerami P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090619
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - *Gene Dosage
MH  - Humans
MH  - Hutchinson's Melanotic Freckle/*classification/*genetics/pathology
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Skin Neoplasms/*classification/*genetics/pathology
EDAT- 2009/06/23 09:00
MHDA- 2009/11/11 06:00
CRDT- 2009/06/23 09:00
PHST- 2009/06/23 09:00 [entrez]
PHST- 2009/06/23 09:00 [pubmed]
PHST- 2009/11/11 06:00 [medline]
AID - S0893-3952(22)02479-6 [pii]
AID - 10.1038/modpathol.2009.93 [doi]
PST - ppublish
SO  - Mod Pathol. 2009 Sep;22(9):1258-62. doi: 10.1038/modpathol.2009.93. Epub 2009 Jun 
      19.