PMID- 19544176
OWN - NLM
STAT- MEDLINE
DCOM- 20090715
LR  - 20091217
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 46
IP  - 5
DP  - 2009 Jun
TI  - Genetic variation of myeloperoxidase gene contributes to atopic asthma 
      susceptibility: a preliminary association study in Russian population.
PG  - 523-8
LID - 10.1080/02770900902818389 [doi]
AB  - BACKGROUND: Recently, we have shown that both antioxidant and oxidant genes are 
      proper candidates for asthma susceptibility genes. OBJECTIVES: In the present 
      study we investigated whether a common polymorphism -463G > A in the promoter of 
      myeloperoxidase (MPO) gene, an enzyme producing hypohalogenic oxidants, is 
      associated with the risk of bronchial asthma. METHODS: We studied 429 unrelated 
      Russian subjects including 215 asthmatic patients and 214 sex- and age-matched 
      healthy controls from Central Russia. The genotyping of the polymorphism -463G > 
      A in the MPO gene was performed by the polymerase chain reaction and the 
      restriction fragment length polymorphism assays. RESULTS: It was found that a 
      carriage of a -463A allele is associated with decreased risk of asthma (OR 0.64 
      95%CI 0.44-0.91, p = 0.013). Furthermore, variant genotypes (-463GA + AA) of the 
      MPO gene were associated with decreased risk of asthma (OR adjusted by age, 
      gender, and immunoglobulin E (IgE) level was 0.63 95%CI 0.42-0.95), but at a 
      borderline statistical significance (Bonferroni corrected p = 0.017). Further 
      analysis revealed that both a -463A allele and the -463GA/AA genotypes are 
      significantly associated with decreased risk of atopic asthma (p = 0.01). No 
      association of the -463G > A polymorphism of the MPO gene with non-atopic asthma 
      has been revealed. We also found that the allele -463A (OR = 0.47 95%CI 
      0.27-0.81, p = 0.01) and the -463GA + AA genotypes (OR 0.43 95%CI 0.24-0.78, p = 
      0.005) are significantly associated with decreased risk of late-onset atopic 
      asthma (the disease onset after 30 years). No association of both allele and 
      genotypes of the polymorphism -463G > A of the MPO gene with early-onset of 
      atopic and non-atopic asthma (the disease before 30 years) was seen. CONCLUSIONS: 
      The results of this study provide novel insights into pathogenesis of bronchial 
      asthma. We put forward a suggestion about a possible mechanism by which the -463G 
      > A polymorphism of the MPO gene is involved into pathogenesis of asthma.
FAU - Polonikov, A V
AU  - Polonikov AV
AD  - Department of Biology, Medical Genetics and Ecology, Kursk State Medical 
      University, Karl Marx Street, 3, Kursk 305041, Russian Federation. 
      polonikov@rambler.ru
FAU - Solodilova, M A
AU  - Solodilova MA
FAU - Ivanov, V P
AU  - Ivanov VP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
EIN - J Asthma. 2009 Nov;46(9):972
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asthma/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Hypersensitivity, Immediate/*genetics
MH  - Male
MH  - Middle Aged
MH  - Peroxidase/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - Risk Factors
MH  - Russia
MH  - Young Adult
EDAT- 2009/06/23 09:00
MHDA- 2009/07/16 09:00
CRDT- 2009/06/23 09:00
PHST- 2009/06/23 09:00 [entrez]
PHST- 2009/06/23 09:00 [pubmed]
PHST- 2009/07/16 09:00 [medline]
AID - 912534221 [pii]
AID - 10.1080/02770900902818389 [doi]
PST - ppublish
SO  - J Asthma. 2009 Jun;46(5):523-8. doi: 10.1080/02770900902818389.