PMID- 19546120
OWN - NLM
STAT- MEDLINE
DCOM- 20090917
LR  - 20211020
IS  - 1465-7333 (Electronic)
IS  - 0022-1503 (Print)
IS  - 0022-1503 (Linking)
VI  - 100 Suppl 1
IP  - Suppl 1
DP  - 2009 Jul-Aug
TI  - Chromosomal mapping of canine-derived BAC clones to the red fox and American mink 
      genomes.
PG  - S42-53
LID - 10.1093/jhered/esp037 [doi]
AB  - High-quality sequencing of the dog (Canis lupus familiaris) genome has enabled 
      enormous progress in genetic mapping of canine phenotypic variation. The red fox 
      (Vulpes vulpes), another canid species, also exhibits a wide range of variation 
      in coat color, morphology, and behavior. Although the fox genome has not yet been 
      sequenced, canine genomic resources have been used to construct a meiotic linkage 
      map of the red fox genome and begin genetic mapping in foxes. However, a more 
      detailed gene-specific comparative map between the dog and fox genomes is 
      required to establish gene order within homologous regions of dog and fox 
      chromosomes and to refine breakpoints between homologous chromosomes of the 2 
      species. In the current study, we tested whether canine-derived gene-containing 
      bacterial artificial chromosome (BAC) clones can be routinely used to build a 
      gene-specific map of the red fox genome. Forty canine BAC clones were mapped to 
      the red fox genome by fluorescence in situ hybridization (FISH). Each clone was 
      uniquely assigned to a single fox chromosome, and the locations of 38 clones 
      agreed with cytogenetic predictions. These results clearly demonstrate the 
      utility of FISH mapping for construction of a whole-genome gene-specific map of 
      the red fox. The further possibility of using canine BAC clones to map genes in 
      the American mink (Mustela vison) genome was also explored. Much lower success 
      was obtained for this more distantly related farm-bred species, although a few 
      BAC clones were mapped to the predicted chromosomal locations.
FAU - Kukekova, Anna V
AU  - Kukekova AV
AD  - James A. Baker Institute for Animal Health, College of Veterinary Medicine, 
      Cornell University, Ithaca, NY 14853, USA. avk5@cornell.edu
FAU - Vorobieva, Nadegda V
AU  - Vorobieva NV
FAU - Beklemisheva, Violetta R
AU  - Beklemisheva VR
FAU - Johnson, Jennifer L
AU  - Johnson JL
FAU - Temnykh, Svetlana V
AU  - Temnykh SV
FAU - Yudkin, Dmitry V
AU  - Yudkin DV
FAU - Trut, Lyudmila N
AU  - Trut LN
FAU - Andre, Catherine
AU  - Andre C
FAU - Galibert, Francis
AU  - Galibert F
FAU - Aguirre, Gustavo D
AU  - Aguirre GD
FAU - Acland, Gregory M
AU  - Acland GM
FAU - Graphodatsky, Alexander S
AU  - Graphodatsky AS
LA  - eng
GR  - EY006855/EY/NEI NIH HHS/United States
GR  - R03TW008098/TW/FIC NIH HHS/United States
GR  - R01 EY006855/EY/NEI NIH HHS/United States
GR  - MH077811/MH/NIMH NIH HHS/United States
GR  - R03 TW008098-01/TW/FIC NIH HHS/United States
GR  - R03 TW008098/TW/FIC NIH HHS/United States
GR  - R03 TW008098-02/TW/FIC NIH HHS/United States
GR  - R01 EY006855-22/EY/NEI NIH HHS/United States
GR  - R01 MH077811/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090621
PL  - United States
TA  - J Hered
JT  - The Journal of heredity
JID - 0375373
SB  - IM
MH  - Animals
MH  - Chromosome Mapping/*veterinary
MH  - Chromosomes, Artificial, Bacterial/*genetics
MH  - Dogs/*genetics
MH  - Foxes/*genetics
MH  - Genome
MH  - Genomics/methods
MH  - In Situ Hybridization, Fluorescence
MH  - Mink/*genetics
PMC - PMC3139363
EDAT- 2009/06/24 09:00
MHDA- 2009/09/18 06:00
PMCR- 2010/07/01
CRDT- 2009/06/24 09:00
PHST- 2009/06/24 09:00 [entrez]
PHST- 2009/06/24 09:00 [pubmed]
PHST- 2009/09/18 06:00 [medline]
PHST- 2010/07/01 00:00 [pmc-release]
AID - esp037 [pii]
AID - 10.1093/jhered/esp037 [doi]
PST - ppublish
SO  - J Hered. 2009 Jul-Aug;100 Suppl 1(Suppl 1):S42-53. doi: 10.1093/jhered/esp037. 
      Epub 2009 Jun 21.