PMID- 19546436
OWN - NLM
STAT- MEDLINE
DCOM- 20091207
LR  - 20231213
IS  - 1592-8721 (Electronic)
IS  - 0390-6078 (Print)
IS  - 0390-6078 (Linking)
VI  - 94
IP  - 8
DP  - 2009 Aug
TI  - Mesenchymal stem cells efficiently inhibit the proinflammatory properties of 
      6-sulfo LacNAc dendritic cells.
PG  - 1151-6
LID - 10.3324/haematol.2008.001735 [doi]
AB  - Mesenchymal stem cells emerged as a promising treatment modality for 
      steroid-refractory graft-versus-host disease, which represents a major 
      complication of allogeneic hematopoietic stem cell transplantation. Dendritic 
      cells (DCs) display an extraordinary capacity to induce T-cell responses and play 
      a crucial role in the pathogenesis of graft-versus-host disease. Here, we 
      investigated the impact of mesenchymal stem cells on the proinflammatory capacity 
      of 6-sulfo LacNAc (slan) dendritic cells, representing a major subpopulation of 
      human blood dendritic cells. Mesenchymal stem cells markedly impair maturation of 
      slanDCs and their ability to secrete proinflammatory cytokines, which was 
      dependent on prostaglandin E(2). In contrast, the release of anti-inflammatory 
      IL-10 was improved by mesenchymal stem cells. Furthermore, mesenchymal stem cells 
      efficiently inhibit slanDC-induced proliferation of CD4(+) and CD8(+) T cells and 
      polarization of naive CD4(+) T lymphocytes into Th1 cells. These results indicate 
      that mesenchymal stem cells significantly impair the high proinflammatory 
      capacity of slanDCs and further substantiate their potential for the treatment of 
      graft-versus-host disease.
FAU - Wehner, Rebekka
AU  - Wehner R
AD  - Institute of Immunology, Medical Faculty, Technical University, Dresden, Germany.
FAU - Wehrum, Diana
AU  - Wehrum D
FAU - Bornhauser, Martin
AU  - Bornhauser M
FAU - Zhao, Senming
AU  - Zhao S
FAU - Schakel, Knut
AU  - Schakel K
FAU - Bachmann, Michael P
AU  - Bachmann MP
FAU - Platzbecker, Uwe
AU  - Platzbecker U
FAU - Ehninger, Gerhard
AU  - Ehninger G
FAU - Rieber, E Peter
AU  - Rieber EP
FAU - Schmitz, Marc
AU  - Schmitz M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090622
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
RN  - 0 (6-sulfo-LacNac)
RN  - 0 (Amino Sugars)
RN  - 0 (Antigens, CD)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Cytokines)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Amino Sugars/immunology
MH  - Antigens, CD/immunology
MH  - B7-2 Antigen/immunology
MH  - CD4-Positive T-Lymphocytes/cytology/immunology
MH  - CD8-Positive T-Lymphocytes/cytology/immunology
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Cytokines/*metabolism
MH  - Dendritic Cells/cytology/immunology/*metabolism
MH  - Flow Cytometry
MH  - HLA-DR Antigens/immunology
MH  - Humans
MH  - Immunoglobulins/immunology
MH  - Interferon-gamma/metabolism
MH  - Interleukin-4/metabolism
MH  - Membrane Glycoproteins/immunology
MH  - Mesenchymal Stem Cells/cytology/*immunology
MH  - CD83 Antigen
PMC - PMC2719037
EDAT- 2009/06/24 09:00
MHDA- 2009/12/16 06:00
PMCR- 2009/08/01
CRDT- 2009/06/24 09:00
PHST- 2009/06/24 09:00 [entrez]
PHST- 2009/06/24 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2009/08/01 00:00 [pmc-release]
AID - haematol.2008.001735 [pii]
AID - 0941151 [pii]
AID - 10.3324/haematol.2008.001735 [doi]
PST - ppublish
SO  - Haematologica. 2009 Aug;94(8):1151-6. doi: 10.3324/haematol.2008.001735. Epub 
      2009 Jun 22.