PMID- 19549135
OWN - NLM
STAT- MEDLINE
DCOM- 20100104
LR  - 20221207
IS  - 1601-0825 (Electronic)
IS  - 1354-523X (Linking)
VI  - 15
IP  - 8
DP  - 2009 Nov
TI  - Association among interleukin-6 gene polymorphism, diabetes and periodontitis in 
      a Chinese population.
PG  - 547-53
LID - 10.1111/j.1601-0825.2009.01584.x [doi]
AB  - OBJECTIVES: Diabetics significantly increase risk for periodontitis. 
      Interleukin-6 (IL-6) gene polymorphism may play certain roles in the progression 
      of periodontitis with diabetes. The purpose of this study was to assess the 
      association among IL-6 gene polymorphisms, type 2 diabetes mellitus (T2DM) and 
      chronic periodontitis (CP) in a Chinese population. MATERIAL AND METHODS: DNA was 
      obtained from 159 patients with CP, 88 patients with T2DM, 110 patients with 
      CP&T2DM and 135 control subjects. The -174/-572/-597 polymorphisms of IL-6 gene 
      were investigated by restriction fragment length polymorphism of polymerase chain 
      reaction products. The results were further confirmed by sequencing. Significance 
      was set at P < 0.008 after Bonferroni correction. RESULTS: Among four groups, 
      CP&T2DM group showed the lowest IL-6-572 CC genotype and C-allele frequencies 
      (54.5% and 74.1%). In this regard, there were significant differences between 
      CP&T2DM group and the control group [P = 0.006, odds ratio (OR) = 0.475, 95% CI: 
      0.279-0.808 and P = 0.002, OR = 0.502, 95% CI: 0.319-0.788 respectively]. 
      Logistic regression with adjustment for age, gender, body mass index, smoking and 
      stress showed no significant difference in terms of IL-6-572 genotypes (P = 
      0.058, OR= 0.523, 95% CI: 0.268-1.022). CONCLUSIONS: The IL-6-572 genotype and 
      allele distributions are unique to subjects with CP&T2DM in a Chinese population.
FAU - Xiao, L M
AU  - Xiao LM
AD  - Guangdong Provincial Stomatological Hospital, Southern Medical University, 
      Guangzhou 510280, China.
FAU - Yan, Y X
AU  - Yan YX
FAU - Xie, C J
AU  - Xie CJ
FAU - Fan, W H
AU  - Fan WH
FAU - Xuan, D Y
AU  - Xuan DY
FAU - Wang, C X
AU  - Wang CX
FAU - Chen, L
AU  - Chen L
FAU - Sun, S Y
AU  - Sun SY
FAU - Xie, B Y
AU  - Xie BY
FAU - Zhang, J C
AU  - Zhang JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090622
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
RN  - 0 (Interleukin-6)
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Chronic Periodontitis/complications/ethnology/*genetics/immunology
MH  - Diabetes Complications/ethnology/genetics/immunology
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics/immunology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-6/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
MH  - Reference Values
EDAT- 2009/06/25 09:00
MHDA- 2010/01/05 06:00
CRDT- 2009/06/25 09:00
PHST- 2009/06/25 09:00 [entrez]
PHST- 2009/06/25 09:00 [pubmed]
PHST- 2010/01/05 06:00 [medline]
AID - ODI1584 [pii]
AID - 10.1111/j.1601-0825.2009.01584.x [doi]
PST - ppublish
SO  - Oral Dis. 2009 Nov;15(8):547-53. doi: 10.1111/j.1601-0825.2009.01584.x. Epub 2009 
      Jun 22.