PMID- 1954978
OWN - NLM
STAT- MEDLINE
DCOM- 19911230
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 199
IP  - 2
DP  - 1991 Jun 25
TI  - Intracerebroventricular administration of endothelins: effects on the supraspinal 
      micturition reflex and blood pressure in the anaesthetized rat.
PG  - 201-7
AB  - Intracerebroventricular (i.c.v.) administration of endothelin-1 (ET-1, 10 and 100 
      pmol/rat) or endothelin-3 (ET-3, 100 pmol/rat) inhibited the supraspinal 
      micturition reflex (SMR) in urethane-anesthetized rats. Guanethidine 
      pretreatment, vagotomy or forced ventilation did not modify the effect of i.c.v. 
      ET-1 on the SMR. Intravenous (i.v.) administration of ET-1 (350 pmol/rat) also 
      blocked the SMR with a delay of about 8 min. Guanethidine pretreatment revealed a 
      stimulatory effect of i.v. ET-1 on the frequency of the SMR and the late 
      inhibition was also reduced. In the isolated rat urinary bladder ET-1, ET-3 and 
      ET-(16-21) induced a dose-related contraction and a small enhancement of the 
      neurogenic contraction caused by electrical field stimulation. Inhibition of 
      bladder motility by i.c.v. administration of ET-1 or ET-3 was paralleled by an 
      increase in blood pressure. Both ET-1 and ET-3, at the same doses which evoked 
      these autonomic effects, also killed some animals. The ET-1-induced increase in 
      blood pressure was not prevented by guanethidine pretreatment or by spinal cord 
      transection. Guanethidine pretreatment also did not modify the pressor response 
      induced by i.v. ET-1. Bilateral cervical vagotomy enhanced the pressor response 
      to i.c.v. ET-1. Forced ventilation prevented the death of some animals following 
      i.c.v. administration of ET-1.
FAU - Lecci, A
AU  - Lecci A
AD  - Pharmacology Department, Menarini, Pharmaceuticals, Florence, Italy.
FAU - Giuliani, S
AU  - Giuliani S
FAU - Santicioli, P
AU  - Santicioli P
FAU - Rovero, P
AU  - Rovero P
FAU - Maggi, C A
AU  - Maggi CA
FAU - Giachetti, A
AU  - Giachetti A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Endothelins)
RN  - ZTI6C33Q2Q (Guanethidine)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Brain/drug effects
MH  - Electric Stimulation
MH  - Endothelins/administration & dosage/*pharmacology
MH  - Guanethidine/pharmacology
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Male
MH  - Muscle Contraction/drug effects
MH  - Rats
MH  - Reflex/drug effects
MH  - Urinary Bladder/*drug effects/physiology
MH  - *Urination
EDAT- 1991/06/25 00:00
MHDA- 1991/06/25 00:01
CRDT- 1991/06/25 00:00
PHST- 1991/06/25 00:00 [pubmed]
PHST- 1991/06/25 00:01 [medline]
PHST- 1991/06/25 00:00 [entrez]
AID - 0014-2999(91)90458-3 [pii]
AID - 10.1016/0014-2999(91)90458-3 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1991 Jun 25;199(2):201-7. doi: 10.1016/0014-2999(91)90458-3.