PMID- 19550952
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20190516
IS  - 1094-4087 (Electronic)
IS  - 1094-4087 (Linking)
VI  - 15
IP  - 25
DP  - 2007 Dec 10
TI  - Ex vivo Characterization of Atherosclerosis using Intravascular Photoacoustic 
      Imaging.
PG  - 16657-66
AB  - The imaging of plaque composition represents one of the important steps in the 
      interventional management of atherosclerosis. Intravascular photoacoustic (IVPA) 
      imaging has the potential to play a major role in the detection and 
      differentiation of an atherosclerotic lesion. The difference in the optical 
      properties of the arterial wall and plaque constituents could be utilized to 
      obtain high resolution photoacoustic images. In this work, through ex vivo 
      imaging studies using a rabbit model of atherosclerosis, we evaluate the ability 
      of IVPA imaging to detect and characterize the plaque. Specifically, the 
      difference in the magnitude of the photoacoustic signals from the free lipids, 
      macrophage foam cells, blood and the rest of the arterial wall were helpful in 
      providing the contrast and detecting the fibro-cellular inflammatory plaque. The 
      constituents identified in the IVPA images were confirmed by the results from 
      histology.
FAU - Sethuraman, Shriram
AU  - Sethuraman S
FAU - Amirian, James H
AU  - Amirian JH
FAU - Litovsky, Silvio H
AU  - Litovsky SH
FAU - Smalling, Richard W
AU  - Smalling RW
FAU - Emelianov, Stanislav Y
AU  - Emelianov SY
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Opt Express
JT  - Optics express
JID - 101137103
EDAT- 2007/12/10 00:00
MHDA- 2007/12/10 00:01
CRDT- 2009/06/25 09:00
PHST- 2009/06/25 09:00 [entrez]
PHST- 2007/12/10 00:00 [pubmed]
PHST- 2007/12/10 00:01 [medline]
AID - 148272 [pii]
AID - 10.1364/oe.15.016657 [doi]
PST - ppublish
SO  - Opt Express. 2007 Dec 10;15(25):16657-66. doi: 10.1364/oe.15.016657.